Antimicrobial resistance

Introduction

Antimicrobials, such as antibiotics, are substances used to kill micro-organisms or to stop them from growing and multiplying. They are commonly used in human and veterinary medicine to treat a wide variety of infectious diseases.

Antimicrobial resistance refers to the ability of micro-organisms to withstand antimicrobial treatments. The overuse or misuse of antibiotics has been linked to the emergence and spread of micro-organisms which are resistant to them, rendering treatment ineffective and posing a serious risk to public health. A well known example of a bacterium that has acquired resistance to multiple antibiotics is Meticillin-resistant Staphylococcus aureus (MRSA).

Resistant bacteria can spread through many routes. When antimicrobial resistance occurs in zoonotic bacteria present in animals and food it can also compromise the effective treatment of infectious diseases in humans.

In the field of food safety, policy-makers need to protect consumers from risks related to the food chain and to establish the best control options to reduce such risks. Scientists and risk assessors are examining the factors which may lead to the presence of antimicrobial resistant bacteria in food and animals to provide appropriate scientific advice to decision-makers.

 Antimicrobial resistance in Europe
Interactive infographic: Antimicrobial resistance in Europe

Milestones

EFSA is working with key EU actors to reduce antimicrobial resistance

October 2017 – EFSA, the European Medicines Agency (EMA) and the European Centre for Disease Prevention and Control (ECDC) establish a set of indicators to help EU Member States assess their progress in reducing the use of antimicrobials.

July 2017 – A report from EFSA, EMA and ECDC presents new data on antibiotic consumption and antibiotic resistance, reflecting improved surveillance across Europe. The report confirms the link between antibiotic consumption and antibiotic resistance in both humans and food-producing animals.

January 2017 – Experts from EFSA and EMA review measures taken in the EU to reduce use of antimicrobials in animals and stress that there is no one-size-fits-all solution. Successful strategies follow an integrated, multifaceted approach which takes into account the local livestock production system and involves all relevant stakeholders.

Interactive infographic: How can we reduce the use of antimicrobials in food producing animals?
 
Interactive infographic: How can we reduce the use of antimicrobials in food producing animals?
 

January 2015 – EFSA, ECDC and EMA publish the first integrated analysis of data from humans and animals. They conclude that the use of certain antimicrobials in animals and humans is associated with resistance.

2011 Since 2011 EFSA and ECDC have been compiling a joint report on antimicrobial resistance in zoonotic bacteria affecting humans, animals and food. This annual report makes an important contribution to work being carried out at European level and supports the European Commission as it develops proposals to fight antimicrobial resistance.

March 2009 – EFSA assesses the public health significance of meticillin-resistant Staphylococcus aureus (MRSA) in animals and foods. It concludes that livestock-associated MRSA represents only a small proportion of all reported MRSA infections in the EU with significant differences between Member States.

April 2008 – EFSA experts examine how food may become a vehicle for transmitting resistant bacteria to humans and make recommendations for preventing and controlling transmission. EFSA publishes further specifications for the harmonised monitoring of antimicrobial resistance in Escherichia coli and enterococci bacteria in animals and foods.

2007 – EFSA publishes specifications for the harmonised monitoring of antimicrobial resistance in two important zoonotic bacteria – Salmonella and Campylobacter – found in animals and foods.

EFSA's role

EFSA provides independent scientific support and advice to risk managers on the risks to human and animal health related to the possible emergence, spread and transfer of antimicrobial resistance in the food chain and in animal populations. EFSA takes an integrated approach to its work on antimicrobial resistance involving a number of its Scientific Panels and Units as it is a concern for the entire food chain.

In its work, EFSA cooperates closely with other relevant EU agencies such as the European Centre for Disease Prevention and Control (ECDC) and the European Medicines Agency (EMA).

Monitoring and analysis of antimicrobial resistance in the food chain

EFSA monitors and analyses the situation on antimicrobial resistance in food and animals across Europe. The Authority is assisted by the Task Force on Zoonoses Data Collection: a pan-European network of national representatives of EU Member States, other reporting countries, as well as the World Health Organisation (WHO) and World Organisation for Animal Health (OIE).

Based on data collected by the EU Member States, EFSA produces in cooperation with ECDC annual European Union Summary Reports on zoonotic infections, food-borne outbreaks and antimicrobial resistance illustrating the evolving situation in Europe. EFSA also publishes baseline survey reports on the prevalence of antimicrobial resistance in the EU in specific animal populations, for instance MRSA in pigs, and provides guidance to national authorities how to carry out their monitoring and reporting activities.

EFSA’s Scientific Panels review the annual reports and make recommendations on prevention and reduction measures.

Risk assessments and recommendations

EFSA’s Scientific Panels assess the risks of antimicrobial resistance and provides scientific advice on control options at the request of risk managers or on its own initiative. This work has included risk assessments by the Panel on Biological Hazards on antimicrobial resistance in the food and feed chain and the public health significance of MRSA in animals and food focusing on the specific type of MRSA found in food-producing animals. The Panel on additives and products or substances used in animal feed assesses the safety of animal feed additives, including the risks related to antibiotic resistance where micro-organisms are involved.

EFSA, ECDC, EMA and the European Commission’s Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) have also published a joint scientific opinion on antimicrobial resistance focused on infections that can be transmitted to humans from animals and food (i.e. zoonoses).

EU framework

To tackle antimicrobial resistance, a holistic, multi-sectorial approach, involving many different sectors (human medicine, veterinary medicine, research, animal husbandry, agriculture, environment, trade and communication) is needed.

The Commission's 2011 action plan against the rising threats from antimicrobial resistance contains 12 actions for implementation with EU member countries and identifies 7 areas where measures are most necessary. A progress report on the AMR Action Plan published in February 2015, shows the state of play of steps taken to address AMR.

A number of risk management measures to combat antimicrobial resistance are in place related to the food chain. EU legislation on zoonoses - animal diseases or infections transmissible between animals and humans - obliges Member States to monitor trends in antimicrobial resistance in zoonoses and other agents that may present a threat to public health.

At international level, countries cooperate through an Intergovernmental Task Force on Antimicrobial Resistance which reports to the Codex Alimentarius Commission. The EU and United States have also created a transatlantic task force on antimicrobial resistance issues.

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