EFSA assesses public health risks of opium alkaloids in poppy seeds

The CONTAM Panel noted that there are few reports of adverse effects arising from the traditional consumption of poppy seeds; however it cannot be assumed that such reactions do not occur from time to time. Morphine-like effects have been observed in humans following consumption of a single portion of a meal containing opium alkaloid-contaminated poppy seeds. The Panel’s scientific experts considered it appropriate therefore to base their risk assessment  A specialised field of applied science that involves reviewing scientific data and studies in order to evaluate risks associated with certain hazards. It involves four steps: hazard identification, hazard characterisation, exposure assessment and risk characterisation. for poppy seeds on exposure Concentration or amount of a particular substance that is taken in by an individual, population or ecosystem in a specific frequency over a certain amount of time. to morphine, which is the most common opium alkaloid found in poppy seeds. The Panel established a health-based guidance value Guidance on safe consumption of substances that takes into account current safety data, uncertainties in these data, and the likely duration of consumption., known as the Acute Reference Dose (ARfD), of 10 μg morphine per kg of body weight, based on the lowest known oral therapeutic dose The total amount of a substance (e.g. a chemical or nutrient) given to, consumed or absorbed by an individual organism, population or ecosystem. of morphine. The Panel considered this to represent the intake level above which food containing opium alkaloid-contaminated poppy seeds could be a health concern.

An exact picture of the consumption of food containing poppy seeds across the EU is currently not available as many countries do not provide specific consumption data or take into account high seasonal consumption. Estimates of exposure were therefore derived from recipes, analyses of poppy seeds and analyses of some food products. The Panel found that consumers of foods containing large amounts of poppy seeds are likely to exceed the ARfD on at least some eating occasions. In addition, if poppy seeds are consumed as a condiment or decoration in bread and fine bakery ware, some consumers, particularly young children, could also on rare occasions exceed the ARfD. The opinion also states that food processing techniques such as washing, soaking, grinding and cooking may reduce the alkaloid content of poppy seeds.

The CONTAM Panel recommends that more data are collected on: levels of opium alkaloids in food products; the varieties of poppy seeds that are available on the European market for food use and their alkaloid content; as well as consumption of foods containing poppy seeds. In addition, the Panel stated that further work in this area should focus not only on morphine, but also on the other alkaloids reported to be present.

The main opium alkaloid in poppy seeds is morphine with lower levels of codeine, thebaine, noscapine and papaverine. The most prominent side effects associated with the medical use of morphine and codeine are sleepiness and breathing difficulties.

The opium poppy is cultivated primarily for medical uses, but its seeds are also used in food in many European Union (EU) countries. In some Central-Eastern European Countries, it is traditional to use poppy seeds widely in foods, including in high amounts in bread, fine bakery ware and desserts. Unground poppy seeds are sometimes used as a condiment or decoration in food.

• Scientific Opinion on the risks for public health related to the presence of opium alkaloids in poppy seeds