in silico
Research theoretical method, particularly involving computer models, to predict the likely toxicological, or other, effects of substances
In silico refers to computer-based methods and simulations used to predict how substances in food—like chemicals, additives, or novel proteins—might behave in the body, including their toxicity, allergenicity, or metabolism. Instead of relying solely on animal or human studies, these methods use models, databases, and algorithms to estimate risks.
EFSA uses in silico approaches to make food safety assessments faster, more efficient, and more ethical. By combining computer predictions with laboratory and experimental data, EFSA can prioritize which substances need further testing, evaluate potential hazards, and provide scientific advice for EU regulations, helping protect consumers while reducing animal testing.