dose addition
A process to establish the response of organisms to a mixture of chemicals with similar toxicity. This involves adding up their individual effects to predict the likely impact of the overall mixture
Dose addition is a concept used in food safety to assess the combined effect of several chemicals that act in a similar way. It assumes that each chemical contributes proportionally to the overall effect, so their combined impact can be estimated by adding up their doses.
EFSA uses dose addition when evaluating exposure to multiple chemicals, such as pesticides or contaminants, that share the same toxic effect. This approach helps EFSA perform cumulative risk assessments and provide advice on safe levels of combined chemical exposure in food, protecting consumers from potential health risks.