Comparison of the Approaches Taken by EFSA and JECFA to Establish a HBGV for Cadmium

Cadmium, meta-analysis, dose-response model, PK models, benchmark dose, hybrid approach
First published in the EFSA Journal
8 February 2011
7 February 2011
Last Updated
10 February 2011. This version replaces the previous one/s.
Scientific Report


EFSA received a mandate from the European Commission (EC) to re-assess the elements linked to the establishment of the health-based guidance value in the opinion on cadmium in food of the EFSA’s CONTAM panel (EFSA, 2009a). The CONTAM Unit asked support from the Assessment Methodology Unit to re-assess the elements leading to the establishment of the health-based guidance value in the opinion taking into account a report established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 2010) where a different health-based guidance value was concluded. In this scientific report, the methodology used by EFSA and its rationale is described in more detail, and supporting evidence for the need of an adjustment factor to establish a health-based guidance value is provided. A comparison between JECFA and EFSA approaches is presented, as well as a sensitivity analysis in relation to the choice of the toxicodynamic variability function used by JECFA in their approach, to illustrate impact when establishing a health-based guidance value.

European Food Safety Authority
amu [at]
EFSA Journal 2011;9(2):2006
Question Number
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