Software for Benchmark Dose Modelling
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The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.
Abstract
In specific contract No 7 issued under the framework agreement OC/EFSA/AMU/2015/02, EFSA requested Open Analytics to extend the Web application for Benchmark Dose Modelling built under specific contracts No 3 and No 4. The Web application is further developed in R with focus on creating a graphical module to evaluate model fit and to modify specific plot settings, as specified in the Technical Annex to Specific Contract No 7. The web application includes the latest developments in PROAST on model averaging for litter quantal data, fitting single models and extending the work on quantal data to ordinal data. The contractor explores in conjunction with EFSA the extension of model families for continuous data, study the recommended number of runs in the model averaging process as well as the performance of model averaging in this context. The module includes the possibility to run analysis on several endpoints and provides a summary comparing results.