quantitative/qualitative structure activity relationships
A set of methods by which the effects of different compounds are related to their molecular structures. It allows the likely adverse or beneficial effects of a particular chemical to be predicted by comparing it with others which have similar structures
QSAR (Quantitative Structure–Activity Relationship) is a computer-based method that predicts how a chemical might behave in the body based on its molecular structure. Instead of testing the substance in animals, QSAR models use existing data to estimate properties such as toxicity, genotoxicity, or potential health effects.
EFSA uses QSAR as part of its in silico tools to support risk assessments of substances like pesticides, food additives, contaminants, and substances in food contact materials. QSAR helps EFSA identify possible hazards early, prioritise substances for further testing, and reduce the need for animal studies in line with ethical principles. While QSAR results are usually not used alone to make final decisions, EFSA combines them with other scientific evidence to strengthen and speed up food safety assessments.