Scrapie: no evidence of threat to humans under real-life conditions

A new study reviewed by EFSA shows that under laboratory conditions Classical scrapie could be transmitted from sheep to mice whose genes have been modified to resemble human genes. This transmission caused a disease similar to sporadic CJD, or “sCJD”, which is a form of Creutzfeldt-Jakob Disease.

CJD is a transmissible Capable of being passed between individuals in the same species, as well as between different species (e.g. from animals to humans). spongiform encephalopathy (TSE) affecting humans. Various forms of CJD are recognised: sporadic CJD is the most common and its origin is uncertain; variant CJD was identified in the 1990s and is closely linked to exposure Concentration or amount of a particular substance that is taken in by an individual, population or ecosystem in a specific frequency over a certain amount of time. – probably through food – to the cattle disease bovine spongiform encephalopathy (BSE).

In their review, EFSA’s experts praise the robustness of the study but conclude that current scientific knowledge does not change the Authority’s previous scientific advice.

EFSA’s experts also conclude that it is not possible to assess scrapie-related public health risks from the consumption of sheep-derived food products.

They highlight that current scientific knowledge on scrapie is limited, e.g. information is lacking on the variability Natural variations observed between members of a population, or observed over time or in different geographical locations; for example, individual variations in susceptibility to a particular toxic chemical.  of different strains, their geographical distribution and how they may affect potential crossover to other species A subdivision of the genus, a species is a group of closely related and similar-looking organisms; for example, in the case of Homo sapiens (humans), the second part of the name (sapiens) represents the species..

Scrapie affects sheep and goats and comes in two variants. Classical scrapie is transmitted through exposure to scrapie-infected animals (e.g. via placentae or milk) and their environment. Scientific evidence suggests that Atypical scrapie, the second variant, is spontaneous and non-contagious. In this opinion EFSA experts have considered both variants, with a particular focus on Classical scrapie, which is the topic of the study under review.

• Scientific Opinion on a request for a review of a scientific publication concerning the zoonotic potential of ovine scrapie prions