EU Summary Report on antimicrobial resistance in zoonotic and indicator bacteria from humans, animals and food in 2013

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Article
European Food Safety Authority
EFSA Journal
EFSA Journal 2015;13(2):4036
doi
10.2903/j.efsa.2015.4036
Acknowledgements

EFSA and ECDC wish to thank the following for the support provided and contributions to this scientific report: members of the Scientific Network for Zoonoses Monitoring Data (EFSA) and the Food and Waterborne Diseases and Zoonoses Network (ECDC) who provided data and reviewed the report; members of the Scientific Network for Zoonoses Monitoring Data for their endorsement of this report; the EFSA staff members Pierre-Alexandre Belœil, Anca-Violeta Stoicescu, Kenneth Mulligan, Francesca Riolo, Cristina Rodriguez Pinacho and Klaudia Chrzastek; ECDC staff member Therese Westrell; EFSA contractors The Animal Health and Veterinary Laboratory Agency of the United Kingdom (Christopher Teale) and The Technical University of Denmark (Helle Korsgaard); and the ECDC contractor The National University of Ireland, Galway (Martin Cormican and Dearbhaile Morris).

European Centre for Disease Prevention and Control
Type
Scientific Report of EFSA
On request from
EFSA
Question Number
EFSA-Q-2014-00118
Approved
20 February 2015
Published in the EFSA Journal
26 February 2015
Affiliation
European Food Safety Authority (EFSA), Parma, Italy; European Centre for Disease Prevention and Control (ECDC), Stockholm , Sweden
Note
Abstract

The antimicrobial resistance data on zoonotic and indicator bacteria in 2013, submitted by 28 EU MSs, were jointly analysed by EFSA and ECDC. Resistance in zoonotic Salmonella and Campylobacter species from humans, animals and food, and resistance in indicator Escherichia coli and enterococci,as well as data on meticillin-resistant Staphylococcus aureus, in animals and food were addressed. ‘Microbiological’ resistance was assessed using epidemiological cut-off (ECOFF) values in animal and food isolates and, where possible, in human isolates. For human isolates interpreted based on clinical breakpoints, the ‘clinically’ resistant and ‘intermediate’ resistant categories were combined into a ‘non-susceptible’ group, resulting in close correspondence with the ECOFF-defined ‘microbiological’ resistance for most antimicrobials. In Salmonella from humans, high proportions of isolates were resistant to ampicillin, sulfonamides and tetracyclines, while proportions of isolates resistant to third-generation cephalosporins and clinically non-susceptible to fluoroquinolones generally remained low. In Salmonella and Escherichia coli isolates from fowl, pigs, cattle and meat thereof, resistance to ampicillin, tetracyclines and sulfonamides was commonly detected, while resistance to third-generation cephalosporins was generally uncommon. High to very high resistance to (fluoro)quinolones was observed in Salmonella from turkeys, fowl and broiler meat. In Campylobacter from humans, a high to very high proportion of isolates were resistant to ciprofloxacin and tetracyclines, while resistance to erythromycin was low to moderate. The resistance to fluoroquinolones in some MSs was extremely high; in such settings, the effective treatment option for human enteric Campylobacter infection may be significantly reduced. High to extremely high resistance to ciprofloxacin, nalidixic acid and tetracyclines was observed in Campylobacter isolates from fowl, broiler meat, pigs and cattle, whereas much lower levels were observed for erythromycin and gentamicin. Increasing trends in ciprofloxacin resistance were observed in Campylobacter from broilers and/or pigs in several MSs. Multi-resistance and co-resistance to critically important antimicrobials in both human and animal isolates were uncommon. A minority of isolates from animals belonging to a few Salmonella serovars (notably Kentucky and Infantis) had a high level of resistance to ciprofloxacin.

Keywords
antimicrobial resistance, zoonotic bacteria, indicator bacteria
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