Scientific Opinion on the identification of pesticides to be included in cumulative assessment groups on the basis of their toxicological profile

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Article
Panel on Plant Protection Products and their Residues
EFSA Journal
EFSA Journal 2013;11(7):3293 [131 pp.].
doi
10.2903/j.efsa.2013.3293
Panel members at the time of adoption
Alf Aagaard, Theo Brock, Ettore Capri, Sabine Duquesne, Metka Filipic, Antonio Hernandez-Jerez, Karen Ildico Hirsch-Ernst, Susanne Hougaard Bennekou, Michael Klein, Thomas Kuhl, Ryszard Laskowski, Matthias Liess, Alberto Mantovani, Colin Ockleford, Bernadette Ossendorp, Daniel Pickford (until June 2014), Robert Smith, Paulo Sousa, Ingvar Sundh, Aaldrik Tiktak, Ton Van Der Linden.
Acknowledgements

The Panel wishes to thank the members of the Working Group on Cumulative Assessment Groups of Pesticides Claudia Bolognesi (until June 2012), Alan Boobis (until June 2012), Antonio Hernandez-Jerez, Karen Ildico Hirsch-Ernst, Susanne Hougaard Bennekou, Andreas Kortenkamp, Kyriaki Machera (until June 2012), Alberto Mantovani, Angelo Moretto (until January 2011), Roland Solecki, Maria Tasheva (until June 2012), Christiane Vleminckx (until June 2012) and the EFSA staff members Charlotte Bergkvist, Federica Crivellente, Edgars Felkers (until March 2012), Frédérique Istace, István Sebestyén (until May 2012), Luc Mohimont, Hans Steinkellner, Andrea Terron and Manuela Tiramani for the support provided to this scientific opinion.

Type
Opinion of the Scientific Committee/Scientific Panel
On request from
EFSA
Question Number
EFSA-Q-2009-00860
Adopted
19 June 2013
Published in the EFSA Journal
12 July 2013
Last Updated
17 November 2014. This version replaces the previous one/s.
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

The European Food Safety Authority asked the Panel on Plant Protection Products and their Residues to develop an Opinion on the identification of pesticides to be included in cumulative assessment groups (CAGs) on the basis of their toxicological profile. In 2008, the PPR Panel adopted an Opinion on the suitability of existing methodologies for cumulative risk assessment of pesticides and a tiered approach was proposed, which was applied to a selected group of triazole pesticides in 2009. The present Opinion suggests a methodology for grouping of pesticides based on phenomenological effects and provides CAGs for the thyroid and nervous system. This approach can be applied even when the underlying biochemical events mediating the effects are not understood, and is based on a standardised and thorough review of Draft Assessment Reports (DARs) supporting the approval of all pesticides in Europe, and on recommendations from the European Commission. Pesticidal active substances exhibiting neurotoxic properties were allocated to CAGs for acute effects on motor, sensory and autonomic divisions of the nervous system and neurochemical endpoints. Chronic effects across the same divisions/endpoints and neuropathological effects were collated. Active substances having adverse effects on the thyroid system were allocated to CAGs for effects either on C-cells/the calcitonin system or on follicular cells/the T3/T4 system. The PPR Panel notes that the resulting groups encompass many pesticides and also that individual pesticides could appear in several groups and therefore the data entries for performing cumulative risk assessment (CRA) are of considerable magnitude. Although some CAGs contain a large number of pesticides, little indication of cumulative risk may be inferred from the size of CAGs per se. The PPR Panel recommends that the methodology is implemented for all major organ/systems but the approach used should be considered specific for pesticides.

Keywords
Cumulative risk assessment, toxicological profile, methodology, cumulative assessment grouping, thyroid, nervous system
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Number of Pages
131