The present document represents the summary of the activities undertaken during the second year of the framework contract (OC/EFSA/SCER/2018/01) with the overall objectives of maintaining, updating and further developing the OpenFoodTox database (“OpenFodTox 2.0”). OpenFoodTox has been developed over the last 8 years to map hazard data as published in EFSA documents (opinions, statements, and conclusions) dealing with chemicals risk assessment of food and feed. The repository holds summary data on identification of chemicals, document descriptors, hazard identification, and hazard characterisation. Overall, OpenFoodTox 2.0 now includeshazard data from more thanfrom 10300 assessments, 2140 EFSA outputs and 5100 chemicals with new entries for 138 new substances, 437 hazard assessments from 181 EFSA documents. The data collection for new data types has been continued with further expansion of the data model to incorporate new data types including physicochemical properties (OHT 1 to 23‐5), degradation and bioaccumulation data (OHT 32 and 33), toxicokinetic data (OHT 58), intermediate effects (OHT 201), “New Approach methodologies (NAMs)” and Exposure Information (OHT 301 to 306). OpenFoodTox content was enriched with physico‐chemical properties and PK/TK data including quantitative values for key parameters (Cmax, AUC, half‐life)obtained from EFSA documents published between 2018 and 2020 and progressively integrated in the database. Overall, 3658 experimental physico‐chemical data records for 522 substances (138 EFSA outputs) and 1986 PK/TK records were added for 315 substances (108 EFSA outputs). Case studies onOHT 201 to report mechanistic data are illustrated. Furthermore, preliminary results on new QSAR models are here presented as part of the design of an in silico integrative tool allowing for the description and prediction of hazard properties of chemicals for “OpenFoodTox 2”.