Scientific Opinion on the safety and efficacy of Danisco® Glycosidase TPT/L (endo-1,4-beta-xylanase and endo-1,3(4)-beta-glucanase) as feed additive for poultry, piglets and pigs for fattening

The additive Danisco^® Glycosidase TPT/L is an enzyme preparation containing endo-1,4-beta-xylanase produced by a genetically modified strain of Trichoderma reesei and endo-1,3(4)-beta-glucanase produced by another strain of Trichoderma reesei. It is available in two forms (TPT and L), both ensuring a minimum activity of 12200 xylanase and 1520 glucanase U/g of additive. With the exception of the safety for the user, the liquid and solid forms of Danisco^® Glycosidase are considered to be equivalent when used to deliver the same enzyme dose. Based on the tolerance trials provided for chickens and turkeys for fattening, laying hens and piglets, the FEEDAP Panel concludes that Danisco^® Glycosidase is safe when used at the maximum recommended dose. These conclusions can be extended to all poultry and to pigs for fattening at the same maximum dose. Based on the results obtained in the studies provided for the two active substances and considering that no interactions between them are expected, the additive is of no concern regarding consumer safety when used as an additive in animal feed. The additive should be considered as a potential eye irritant and a skin and respiratory sensitiser. However, the risk resulting from inhalation exposure for the solid formulation is low. No risks for the environment are expected and no further environmental risk assessment is required. The results provided evidence of the efficacy of Danisco^® Glycosidase in chickens and turkeys for fattening, laying hens, piglets and pigs for fattening, when added to feed at the respective intended minimum recommended doses. These conclusions can be extended to all poultry species. However, the FEEDAP Panel notes that the actual effective dose was approximately 50 % higher than the intended dose.