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Feasibility study Open MCRA

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Disclaimer: The present document has been produced and adopted by the bodies identified above as authors. In accordance with Article 36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the authors in the context of a grant agreement between the European Food Safety Authority and the authors. The present document is published complying with the transparency principle to which the Authority is subject. It cannot be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.


This report presents the results of a feasibility study for improving transparency and accessibility of the models implemented in the Monte Carlo Risk Assessment (MCRA) web platform for assessing the risk of combined exposure to multiple chemicals via multiple exposure routes. It provides an overview of the history and current use of the web platform and its scientific and regulatory context. The technical infrastructure of the current MCRA web platform and the modular design of the various models of MCRA are described. Based on selected user stories, user requirements are established, and suggestions are made for possible designs of an open source collection of MCRA models. Technical options are listed for code organisation, programming language, interfacing and containerisation, data organisation, storage and licensing.Also, the role of the MCRA web platform is discussed. The report ends with a suggested approach and next steps, includinga discussion on the need for a governance structure for sustainable development of Open MCRA.

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