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Statistical re-analysis of the Biel maze data of the Stump et al (2010) study: "Developmental neurotoxicity study of dietary bisphenol A in Sprague-Dawley rats"

on the Wiley Online Library



The Biel maze data presented by Stump et al. (2010) were reanalysed by EFSA using statistical methods that took the censoring into consideration along with key experimental and design features. The results showed that it cannot be concluded that there is equivalence between the control group and BPA for neurotoxicity variables (i.e. time to escape and number of errors). Hence, statistically, the possibility of an effect of BPA on the neurotoxicity variables can neither be confirmed nor ruled out. After accounting for key design elements in the modelling there is still large variation in the hazard ratios for the dose effect. This indicates that the Biel maze test as performed by Stump et al. (2010) does not have the potential to demonstrate equivalence of BPA compared to a control. Therefore this study should be considered as being inconclusive.

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