MenaQ7® and maintenance of the elastic properties of the arteries: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

menaquinone‐7, MenaQ7®, arterial stiffness, arterial elasticity, health claim
First published in the EFSA Journal
31 Enero 2020
Adopted
27 Noviembre 2019
Type
Scientific Opinion

Competing interests: A waiver was granted to an expert of the working group, Jean‐Louis Bresson. Pursuant to Article 21(6) of the afore‐mentioned Decision, the concerned expert was allowed to take part in the discussion and in the drafting phase of the scientific output.

Abstract

Following an application from NattoPharma ASA submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Ireland, the EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to MenaQ7® and maintenance of the elastic properties of the arteries. The scope of the application was proposed to fall under a health claim based on newly developed scientific evidence. The food proposed by the applicant as the subject of the health claim is MenaQ7®, which contains 97% menaquinone‐7 by weight. The Panel considers that MenaQ7® is sufficiently characterised. The claimed effect proposed by the applicant is ‘improves arterial stiffness’. Upon a request from EFSA, the applicant agreed that the claimed effect is maintenance of elastic properties of the arteries (by measuring the arterial stiffness). The Panel considers that maintenance of the elastic properties of the arteries is a beneficial physiological effect. No conclusions could be drawn from the three human intervention studies submitted for scientific substantiation of the claim. In the absence of evidence for an effect of MenaQ7® on maintenance of the elastic properties of the arteries in vivo in humans, the studies on the proposed mechanisms by which the food/constituent could exert the claimed effect cannot be used as a source of evidence for the scientific substantiation of the claim. The Panel concludes that a cause and effect relationship has not been established between the consumption of MenaQ7® and maintenance of the elastic properties of the arteries.

Panel members at the time of adoption

Dominique Turck, Jacqueline Castenmiller, Stefaan De Henauw, Karen Ildico Hirsch‐Ernst, John Kearney, Helle Katrine Knutsen, Alexandre Maciuk, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Carmen Pelaez, Kristina Pentieva, Alfonso Siani, Frank Thies, Sophia Tsabouri and Marco Vinceti.
Panel on Nutrition, Novel Foods and Food Allergens
Contact
NDA.admin [at] efsa.europa.eu
doi
10.2903/j.efsa.2020.5949
EFSA Journal 2020;18(1):5949
Question Number
On request from
Competent Authority of Ireland following an application by NattoPharma ASA.