Efficacy of iron chelates of lysine and glutamic acid as feed additive for all animal species

nutritional additives, compounds of trace elements, iron chelates of lysine and glutamic acid, ProPath Fe, efficacy
First published in the EFSA Journal
12 June 2020
25 May 2020
Scientific Opinion


Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of iron chelates of lysine and glutamic acid (Iron‐LG) as nutritional feed additive for all animal species. The European Commission request followed an opinion of the FEEDAP Panel published in 2019; in that opinion the Panel could not conclude on the efficacy of the additive. The applicant submitted additional information to allow the FEEDAP Panel to complete its assessment; these additional data, related to the efficacy of the additive, are the subject of this opinion. Three studies were provided, one each with weaned piglets, pigs for fattening and laying hens. In the study in laying hens, improvements in iron content in egg yolk, iron in serum and in other iron‐related blood endpoints were observed. Based on the results of this study, the FEEDAP Panel concluded that the additive is a source of bioavailable iron, comparable to the standard inorganic iron source, and therefore, the additive is efficacious in meeting the animals’ requirements; the results of the study in pigs for fattening supported the bioavailability of Iron‐LG. The conclusion drawn by the Panel could be extrapolated to all animal species and categories.

Panel members at the time of adoption

Giovanna Azimonti, Vasileios Bampidis Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Mojca Kos Durjava, Maryline Kouba, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa and Ruud Woutersen.
Panel on Additives and Products or Substances used in Animal Feed
feedap [at] efsa.europa.eu
EFSA Journal 2020;18(6):6164
Question Number
On request from
European Commission