Extensive Literature Search, Selection for Relevance and Data Extraction of Studies Related to the Toxicity of PCDD/Fs and DL‐PCBs in Experimental Animals

dioxin, PCDD/Fs, DL-PCBs, toxicology in vivo, animal model
First published in EFSA Supporting Publications
20. November 2018
16. November 2018
External Scientific Report

The present document has been produced and adopted by the bodies identified above as author(s). This task has been carried out exclusively by the author(s) in the context of a contract between the European Food Safety Authority and the author(s), awarded following a tender procedure. The present document is published complying with the transparency principle to which the Authority is subject. It may not be considered as an output adopted by the Authority. The European Food Safety Authority reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.


Polychlorinated dibenzodioxins (PCDD), polychlorinated dibenzofurans (PCDFs) and dioxin‐like polychlorinated biphenyls (DL‐PCBs) are detected ubiquitously in the environment, diet and human tissues. The European Food Safety Authority (EFSA) CONTAM Panel received a mandate from the European Commission for a scientific opinion on the risks for human and animal health related to the presence of dioxins and DL‐PCBs in food and feed. To support preparatory work for the hazard identification and characterisation steps in the human risk assessment, EFSA outsourced an extensive literature search (ELS) followed by relevance assessment and data extraction to wca environment Ltd. In agreement with EFSA's requirements, wca developed two tailored search strategies to retrieve studies pertinent to the toxicity of the seventeen 2,3,7,8‐substituted dioxins (PCDDs) and furans (PCDFs) and twelve DL‐PCBs in experimental animals. The extensive literature search retrieved 4,544 and 559 articles in Web of Science and PubMed, respectively. 182 duplicates were found between databases. A total of 4,921 articles were imported into DistillerSR®. Relevant papers were selected on the basis of eligibility screening, in duplicate by two experienced toxicologists. Predefined relevant information was extracted from 272 references in the DistillerSR® database

biocontam [at] efsa.europa.eu
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