EFSA Journal

Stakeholder workshop “Problem formulation for the environmental risk assessment of gene drive modified insects” (15 May 2019, Brussels)

Recent advances in molecular and synthetic biology are enabling the engineering of gene drives that spread genes of interest through interbreeding populations at a frequency greater than the rate expected by simple Mendelian inheritance. At present, insec ...

Guidance of EFSA on risk assessments for active substances of plant protection products that have stereoisomers as components or impurities and for transformation products of active substances that may have stereoisomers

In response to the request of the European Commission to EFSA, this document provides guidance on the information necessary to perform the risk assessment of plant protection active substances that contain stereoisomers in their composition as active comp ...

Guidance on the use of the Threshold of Toxicological Concern approach in food safety assessment

The Scientific Committee confirms that the Threshold of Toxicological Concern (TTC) is a pragmatic screening and prioritisation tool for use in food safety assessment. This Guidance provides clear step‐by‐step instructions for use of the TTC approach. The ...

EFSA Workshop on in vitro comparative metabolism studies in regulatory pesticide risk assessment

The European Union (EU) pesticides Regulation established that in vitro comparative metabolism studies shall be performed. At present an Organisation for Economic Co‐operation and Development (OECD) test guideline for this kind of studies is not availab ...

EFSA Scientific Colloquium 24 – 'omics in risk assessment: state of the art and next steps

In recent years, the development of innovative tools in genomics, transcriptomics, proteomics and metabolomics (designated collectively as 'omics technologies) has opened up new possibilities for applications in scientific research and led to the ava ...

Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009

This Guidance describes how to perform hazard identification for endocrine-disrupting properties by following the scientific criteria which are outlined in Commission Delegated Regulation (EU) 2017/2100 and Commission Regulation (EU) 2018/605 for biocidal ...

EFSA Scientific Colloquium 23 – Joint European Food Safety Authority and Evidence‐Based Toxicology Collaboration Colloquium Evidence integration in risk assessment: the science of combining apples and oranges 25–26 October 2017 Lisbon, Portugal

In evidence‐based scientific assessments, evidence synthesis is the step that occurs after collecting the data relevant to a clearly formulated research question and appraising the validity of the studies selected for the assessment, according to structur ...

Conference Report on the “Use of Epidemiological findings in Regulatory Pesticide Risk Assessment”

In 2013, as a follow up of a systematic review of epidemiological studies published from 2006 to 2012 investigating the association between pesticide exposure and many health outcome, the European Food Safety Authority (EFSA) lauched a project with a mand ...

Use of EFSA Pesticide Residue Intake Model (EFSA PRIMo revision 3)

Since 2007, the EFSA PRIMo (Pesticide Residue Intake Model), an Excel-based calculation spreadsheet, is the standard tool used at EU level to perform the dietary risk assessment for pesticide residues in the framework of setting and reviewing of maximum r ...

EFSA Guidance Document for predicting environmental concentrations of active substances of plant protection products and transformation products of these active substances in soil

This EFSA Guidance Document provides guidance for the exposure assessment of soil organisms to plant protection products (PPPs) and their transformation products in accordance with Regulation (EC) No. 1107/2009 of the European Parliament and the Council. ...

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