There is a fundamental change in thinking within the regulatory community due to a better understanding of the underlying biology of adverse effects to human health and the environment. The development of alternatives to use laboratory animals has become ...
This scientific report provides a review of modern methodologies and tools to depict toxicokinetic and toxicodynamic processes and their application for the human hazard assessment of chemicals. The application of these methods is illustrated with example ...
This guidance defines the assessment process and the criteria that will be applied by the Animal Health and Welfare Panel to studies on known new or modified legal stunning interventions to determine their suitability for further assessment. The criteria ...
Council Directive 2007/43/EC on the protection of chickens kept for meat production requires Member States to submit to the Commission the results of a data collection of welfare indicators in broiler slaughterhouses. The Commission prepared a draft docum ...
The in vivo alkaline Comet assay detects primary DNA damage in various organs and tissues of exposed animals and can be used to assess the genotoxicity of a great variety of chemical compounds, which include food additives, flavourings, food contact mater ...
During the ten-year period since the creation of EFSA, two scientific panels of EFSA, the former Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC Panel) and the Scientific Panel on Food Additives and ...
The EFSA Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (AFC Panel) and the subsequent Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF Panel) have undertaken evaluations of the safet ...
This guidance document refers to the applications for authorisation of a new food additive or to a modification of an already authorised food additive, combining in a single document the description of the data requirements and their context, and also a d ...
No abstract available doi: 10.2903/j.efsa.2012.2539 Question Number: EFSA-Q-2010-01162 Journal Number: EFSA Journal 2012;10(1):2539 Panels: Panel on Additives and Products or Substances used in Animal Feed Panel members at the time of adoption: Gabri ...
Following a request from the European Commission, the Scientific Committee developed principles and guidance for the establishment of protocols for 90-day whole food/feed studies in rodents. The guidance complements the OECD Test guideline 408 and provide ...