Scientific Opinion on the safety and efficacy of vitamin B1 (thiamine mononitrate and thiamine hydrochloride) as a feed additive for all animal species based on a dossier submitted by DSM Nutritional Products

Nutritional additive, vitamins and provitamins, vitamin B1, thiamine hydrochloride, thiamine mononitrate, safety
First published in the EFSA Journal
3. November 2011
Adopted
11. Oktober 2011
Type
Scientific Opinion

Abstract

Thiamine mononitrate administered via feed and thiamine hydrochloride via water for drinking are safe for the target animals having a wide margin of safety. The use of thiamine mononitrate and thiamine hydrochloride as additives in animal nutrition is safe for consumers. Since no data on inhalation toxicity of thiamine mononitrate and thiamine hydrochloride has been provided, inhalation of dust is considered as potentially hazardous. Diluted solutions of thiamine mononitrate were not irritant to skin and eyes, the pure substances have not been tested. Thiamine mononitrate and thiamine hydrochloride are regarded as skin and eye irritants. On the basis of published literature, thiamine should be considered as a sensitiser. A risk for the environment resulting from the use of thiamine mononitrate and thiamine hydrochloride in animal nutrition is not foreseen. Thiamine mononitrate and thiamine hydrochloride are regarded as effective sources of vitamin B1.

Panel members at the time of adoption

Gabriele Aquilina, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Joop de Knecht, Noël Dierick, Mikolaj Antoni Gralak, Jürgen Gropp, Ingrid Halle, Christer Hogstrand, Reinhard Kroker, Lubomir Leng, Anne-Katrine Lundebye Haldorsen, Secundino Lopez Puente, Alberto Mantovani, Giovanna Martelli, Miklós Mézes, Derek Renshaw, Maria Saarela, Kristen Sejrsen, Johannes Westendorf
Panel on Additives and Products or Substances used in Animal Feed
Contact
feedap [at] efsa.europa.eu
doi
10.2903/j.efsa.2011.2413
EFSA Journal 2011;9(11):2413
Question Number
On request from
European Commission