Safety and efficacy of l‐tryptophan produced by fermentation with Corynebacterium glutamicum KCCM 80176 for all animal species

tryptophan,Corynebacterium glutamicumKCCM 80176, amino acid, nutritional additive,safety, efficacy
First published in the EFSA Journal
18 giugno 2019
Adopted
16 maggio 2019
Type
Scientific Opinion

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on l‐tryptophan produced by fermentation with a genetically modified strain of Corynebacterium glutamicum (KCCM 80176) when used as a nutritional additive in feed and water for drinking for all animal species. Viable cells of the production strain and its recombinant DNA were not detected in the additive. l‐Tryptophan manufactured by fermentation using Cglutamicum KCCM 80176 does not give rise to any safety concern with regard to the genetic modification of the production strain. The use of l‐tryptophan produced using Cglutamicum KCCM 80176 in supplementing feed to compensate for tryptophan deficiency in feedingstuffs is safe for non‐ruminant target species and in ruminants when a rumen‐protected form is used. The use of l‐tryptophan produced by Cglutamicum KCCM 80176 in animal nutrition presents no safety concerns to consumers of animal products. l‐Tryptophan produced by Cglutamicum KCCM 80176 is considered not toxic by inhalation, not irritant to skin or eyes and not a dermal sensitiser. l‐Tryptophan produced by Cglutamicum KCCM 80176 is safe for the environment. l‐Tryptophan produced by Cglutamicum KCCM 80176 is regarded as an effective source of the amino acid l‐tryptophan for all non‐ruminant species. If l‐tryptophan is intended for use in ruminants, it should be protected from ruminal degradation.

Substances
L-tryptophan
Cas: 73-22-3
Inchi: InChI=1S/C11H12N2O2/c12-9(11(14)15)5-7-6-13-10-4-2-1-3-8(7)10/h1-4,6,9,13H,5,12H2,(H,14,15)/t9-/m0/s1
Iupac: (2S)-2-amino-3-(1H-indol-3-yl)propanoic acid

Panel members at the time of adoption

Giovanna Azimonti, Vasileios Bampidis, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Maryline Kouba, Mojca Kos Durjava, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa and Ruud Woutersen.
Panel on Additives and Products or Substances used in Animal Feed
Contact
feedap [at] efsa.europa.eu
doi
10.2903/j.efsa.2019.5729
EFSA Journal 2019;17(6):5729
Question Number
On request from
European Commission
Disclaimer
Relevant information or parts of this scientific output have been blackened in accordance with the confidentiality requests formulated by the applicant pending a decision thereon by the European Commission. The full output has been shared with the European Commission, EU Member States and the applicant. The blackening will be subject to review once the decision on the confidentiality requests is adopted by the European Commission.