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Scientific Opinion on safety and efficacy of CRINA® Poultry Plus (preparation of benzoic acid and essential oil compounds) as feed additive for chickens for fattening

EFSA Journal 2012;10(3):2620 [22 pp.]. doi:10.2903/j.efsa.2012.2620
  EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) Panel Members Gabriele Aquilina, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Joop de Knecht, Noël Albert Dierick, Mikolaj Antoni Gralak, Jürgen Gropp, Ingrid Halle, Christer Hogstrand, Reinhard Kroker, Lubomir Leng, Secundino López Puente, Anne-Katrine Lundebye Haldorsen, Alberto Mantovani, Giovanna Martelli, Miklós Mézes, Derek Renshaw, Maria Saarela, Kristen Sejrsen and Johannes Westendorf Acknowledgment The Panel wishes to thank the members of the Working Group on CRINA Poultry Plus, including Guido Rychen, for the preparatory work on this scientific opinion. Contact FEEDAP@efsa.europa.eu
Type: Opinion of the Scientific Committee/Scientific Panel On request from: European Commission Question number: EFSA-Q-2010-01130 Adopted: 07 March 2012 Published: 23 March 2012 Affiliation: European Food Safety Authority (EFSA), Parma, Italy
Abstract

CRINA® Poultry Plus (CPP) is a feed additive consisting on seven active substances: benzoic acid (83 %), thymol (1.9 %), eugenol (1 %), benzylsalicylate (0.3 %), piperine (0.1 %), isoamylsalicylate (0.1 %) and trans-anethole (0.1 %). It is intended to be used as a zootechnical additive in complete feed for chickens for fattening (300-450 mg CPP/kg feed) to favourably affect their performance. Given the inconsistency of the data and the suggestion of adverse effects, albeit not dose-related, the FEEDAP Panel is unable to conclude on the safety of the additive at the dose range proposed. None of the components of CPP are genotoxic and in vitro assays made with the additive gave no indication of a genotoxic potential. No metabolism/residue data are available for eugenol and piperine in chickens for fattening. Consequently, the FEEDAP Panel cannot draw any final conclusion on the safety for the consumer of CPP used as feed additive in chickens for fattening. CPP should be considered as irritant for the skin and eyes, as well as skin sensitiser; no adverse effects upon inhalation are to be expected. In the absence of data on the environmental fate of piperine, isoamylsalicylate and benzylsalicylate, or the additive itself, the safety for the environment cannot be assessed. A significant effect relative to performance was shown in only one of the eight studies taken for the demonstration of efficacy. There is insufficient evidence that CPP at the recommended dose can improve the zootechnical performance of chickens. The sensory properties of the meat from chickens fed CPP are not affected.

© European Food Safety Authority, 2012

Summary

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety for the target animal(s), consumer, user and the environment and the efficacy of the product CRINA® Poultry Plus as feed additive for chickens for fattening.

CRINA® Poultry Plus (CPP) is a feed additive consisting on seven active substances: benzoic acid (83 %), thymol (1.9 %), eugenol (1 %), benzylsalicylate (0.3 %), piperine (0.1 %), isoamylsalicylate (0.1 %) and trans-anethole (0.1 %). It is intended to be used as a zootechnical additive (functional group “other zootechnical additives”) in complete feed for chickens for fattening at the dose of 300-450 mg/kg complete feed.

Given the inconsistency of the data and the suggestion of adverse effects, albeit not dose-related, the FEEDAP Panel is unable to conclude on the safety of the additive at the dose range proposed.

None of the components of CPP are genotoxic and in vitro assays made with the additive gave no indication of a genotoxic potential. No metabolism/residue data are available for eugenol and piperine in chickens for fattening. Consequently, the FEEDAP Panel cannot draw any final conclusion on the safety for the consumer of CPP used as feed additive in chickens for fattening.

The FEEDAP Panel considers that the product should be treated as irritant for the skin and eyes, as well as skin sensitiser. Given the particle size distribution and low dusting potential of CPP, no adverse effects upon inhalation are to be expected.

In the absence of data on the environmental fate of piperine, isoamylsalicylate and benzylsalicylate, or the additive itself, the safety for the environment cannot be assessed.

There is insufficient evidence that CPP at the recommended dose can improve the zootechnical performance of chickens. The sensory properties of the meat from chickens fed CPP are not affected.

Keywords

Zootechnical additive, benzoic acid, thymol, eugenol, piperine, safety, efficacy