Safety and efficacy of a super critical carbon dioxide extract of Humulus lupulus L. flos when used as a feed flavouring for all animal species

sensory additives, flavouring compounds, Humulus lupulus (L.) flos, hop, supercritical carbon dioxide, beta-acids, safety
First published in the EFSA Journal
30 octobre 2018
3 octobre 2018
Scientific Opinion


Following a request from the European Commission, the EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the safety and efficacy of a super critical carbon dioxide extract of Humulus lupulus L. flos (hop strobiles) when used as a sensory feed additive for all animal species. The additive is specified to containing 40% beta acids and less than 0.2% alpha acids. Known substances of concern ■■■■■ were not detected. It is intended for use as a sensory additive for all animal species at a maximum application rate of 50 mg additive/kg complete feed. Tolerance studies were provided with weaned piglets, chickens for fattening, dairy cows and fish in support of the application for all animal species. However, the FEEDAP Panel could only conclude that the additive is safe for weaned piglets, pigs for fattening and minor growing porcine species at the maximum proposed application rate. No concerns for consumer safety were identified for the use of the additive at the proposed use level in animal nutrition. In the presence of water, the additive is corrosive to skin and eyes. The additive is a potential respiratory and skin sensitiser. Use of the additive in animal production is not expected to pose a risk for the terrestrial or fresh water environment. Since harvested hop and its extracts are recognised to flavour food and its function in feed would be essentially the same as that in food, no further demonstration of efficacy is considered necessary.

Panel members at the time of adoption

Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Birgit Dusemund, Maryline Kouba, Mojca Kos Durjava, Marta López‐Alonso, Secundino López Puente, Francesca Marcon, Baltasar Mayo, Alena Pechová, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa and Ruud Woutersen.
Panel on Additives and Products or Substances used in Animal Feed
feedap [at]
EFSA Journal 2018;16(10):5462
Question Number
On request from
European Commission
Relevant information or parts of this scientific output have been blackened in accordance with the confidentiality requests formulated by the applicant pending a decision thereon by the European Commission. The full output has been shared with the European Commission, EU Member States and the applicant. The blackening will be subject to review once the decision on the confidentiality requests is adopted by the European Commission.