Scientific Opinion on Flavouring Group Evaluation 224 (FGE.224): Consideration of genotoxic potential for two α,β-unsaturated thiophenes from subgroup 5.2 of FGE.19 by EFSA

FGE.224, alpha,beta-unsaturated thiophenes, α,β-unsaturated thiophenes, Subgroup 5.2, FGE.19
First published in the EFSA Journal
20 février 2013
31 janvier 2013
Last Updated
10 avril 2013. This version replaces the previous one/s.
Scientific Opinion


The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of two flavouring substances from subgroup 5.2 of FGE.19 in the Flavouring Group Evaluation 224 (FGE.224). The Flavour Industry has provided additional genotoxicity studies for one of the two substances in FGE.224, namely 5-methyl-2-thiophenecarbaldehyde [FL-no: 15.004]. The data requested by EFSA for the other substance, 3-acetyl-2,5-dimethylthiophene [FL-no: 15.024] of FGE.224 will be provided subsequently according to the Flavour Industry. Based on the new data the Panel concluded that 5-methyl-2-thiophenecarbaldehyde does not give rise to concern with respect to genotoxicity and can accordingly be evaluated using the Procedure. For the other substance in subgroup 5.2, 3-acetyl-2,5-dimethylthiophene, the requested genotoxicity data are still pending and no conclusion could be drawn in the present FGE.

Panel members at the time of adoption

Ulla Beckman Sundh, Mona-Lise Binderup, Claudia Bolognesi, Leon Brimer, Laurence Castle, Alessandro Di Domenico, Karl-Heinz Engel, Roland Franz, Nathalie Gontard, Rainer Gürtler, Trine Husøy, Klaus-Dieter Jany, Martine Kolf-Clauw, Catherine Leclercq, Wim Mennes, Maria Rosaria Milana, Iona Pratt, Kettil Svensson, Maria de Fatima Tavares Poças, Fidel Toldra and Detlef Wölfle.
Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
cef [at]
EFSA Journal 2013;11(2):3093
Question Number
On request from
European Commission