Scientific Opinion on the efficacy of Bactocell (Pediococcus acidilactici) when used as a feed additive for fish

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Article
EFSA Journal 2012;10(9):2886 [6 pp.].
doi
10.2903/j.efsa.2012.2886
EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP)
Panel Members
Gabriele Aquilina, Alex Bach, Vasileios Bampidis, Maria De Lourdes Bastos, Gerhard Flachowsky, Josep Gasa-Gasó, Mikolaj Gralak, Christer Hogstrand, Lubomir Leng, Secundino López-Puente, Giovanna Martelli, Baltasar Mayo, Derek Renshaw, Guido Rychen, Maria Saarela, Kristen Sejrsen, Patrick Van Beelen, Robert John Wallace and Johannes Westendorf
Acknowledgement

The Panel wishes to thank the members of the Working Group on Micro-organisms, including Pier Sandro Cocconcelli, Andrew Chesson, Anne-Katrine Lundebye Haldorsen and Ingrid Halle, for the preparatory work on this scientific opinion.

Type
Opinion of the Scientific Committee/Scientific Panel
On Request From
European Commission
Question Number
EFSA-Q-2012-00441
Adopted
11 Septembre 2012
Published
24 Septembre 2012
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Article (137.38 KB)137.38 KB
Abstract

Bactocell is a feed additive based on viable cells of a strain of Pediococcus acidilactici. This product is already authorised for several species including salmonids. EFSA was requested to assess the efficacy of Bactocell when used as a zootechnical additive (other zootechnical additives) in all fish. The FEEDAP Panel in an earlier opinion concluded that the additive was able to produce a beneficial effect by increasing the number of well-conformed salmonids. However, in the absence of any information on the mode of action, the Panel was unable to predict whether the additive would be effective in non-salmonid fish. In two studies performed with seabass, deformation of the spine was assessed by histological examination and image analysis, and in one study mineralisation was examined using a semi-quantitative staining method of calcification in the whole body. These showed that Bactocell has the potential to produce a beneficial effect in development, increasing the proportion of well conformed fish. The effects seen were comparable to those seen earlier in salmonids. Taking the data on seabass and salmonids together, the FEEDAP Panel concludes that Bactocell has the potential to reduce bone deformation in developing fish at the dose of 1 x 109 CFU/kg of complete feedingstuffs.

Summary

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on the efficacy of Bactocell when used as a zootechnical additive (other zootechnical additives) for all fish. Bactocell is a feed additive based on viable cells of a strain of Pediococcus acidilactici. This product is already authorised for several species including salmonids.

The FEEDAP Panel in an earlier opinion concluded that the additive was able to produce a beneficial effect by increasing the number of well-conformed salmonids. However, in the absence of any information on the mode of action, the Panel was unable to predict whether the additive would be effective in non-salmonid fish.

In two studies performed with seabass, deformation of the spine was assessed by histological examination and image analysis, and in one study mineralisation was examined using a semi-quantitative staining method of calcification in the whole body. These showed that Bactocell has the potential to produce a beneficial effect in development, increasing the proportion of well conformed fish. The effects seen were comparable to those seen earlier in salmonids.

Taking the data on seabass and salmonids together, the FEEDAP Panel concludes that Bactocell has the potential to reduce bone deformation in developing fish at the dose of 1 x 109 CFU/kg of complete feedingstuffs. This dose is derived from two studies with trout and one with seabass.

Keywords
Zootechnical additive, Bactocell, Pediococcus acidilactici, seabass, efficacy, bone deformity
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Number of Pages
6