An international pooled analysis for obtaining a benchmark dose for environmental lead exposure in children

lead, benchmark dose, intellectual function, children
First published in EFSA Supporting Publications
20 April 2010
External Scientific Report

The present document has been produced and adopted by the bodies identified above as authors. In accordance with Article 36 of Regulation (EC) No 178/2002, this task has been carried out exclusively by the authors in the context of a grant agreement between the European Food Safety Authority and the authors. The present document is published complying with the transparency principle to which the European Food Safety Authority is subject. It may not be considered as an output adopted by EFSA. EFSA reserves its rights, view and position as regards the issues addressed and the conclusions reached in the present document, without prejudice to the rights of the authors.


Lanphear and co-workers (2005) carried out an international pooled analysis from seven cohort studies to investigate the effect of low-level environmental lead exposure on children’s intellectual function. The objective of this report produced by the University of Copenhagen was to perform a benchmark dose (BMD) modelling using the raw data obtained with permission from the seven individual cohort studies summarised by Lanphear and co-workers in 2005 on the effect of lead on intellectual function in children. A benchmark response (BMR) of 1 full Intelligence Quotient (IQ) point (BMR01) was used to derive a BMD and its 95 %-confidence lower bound (BMDL) for a 1 % change on human intellectual function due to lead using available dose-effect models based on this study.

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