Inability to assess the safety of stannic chloride added for nutritional purposes as a source of tin in food supplements and the bioavailability of tin from this source based on the supporting dossier [1]- Scientific Statement of the Panel on Additives and Nutrient Sources added to Food (ANS)

Tabs

Article
Panel on Food Additives and Nutrient Sources Added to Food
doi
10.2903/j.efsa.2008.885
Panel members at the time of adoption
F. Aguilar, U.R. Charrondiere, B. Dusemund, P. Galtier, J. Gilbert, D.M. Gott, S. Grilli, R. Guertler, G.E.N. Kass, J. Koenig, C. Lambré, J-C. Larsen, J-C. Leblanc, A. Mortensen, D. Parent-Massin, I. Pratt, I. Rietjens, I. Stankovic, P. Tobback, T. Verguieva, R. Woutersen.
Acknowledgements

The European Food Safety Authority wishes to thank the members of the Working Group A
on Food Additives and Nutrient Sources of the ANS Panel for the preparation of this statement: F. Aguilar, N. Bemrah, P. Galtier, J. Gilbert, S. Grilli, R. Guertler, G.E.N. Kass, C.
Lambré, J.C. Larsen, J-C. Leblanc, A. Mortensen, I. Pratt, I. Stankovic.

Type
Statement of the Scientific Committee/Scientific Panel
Question Number
EFSA-Q-2006-224
Adopted
26 November 2008
Published
10 December 2008
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Download Article (35.95 KB)
Abstract

No abstract available

Summary

Following a request from the Commission to the European Food Safety Authority (EFSA), the Scientific Panel on Additives and Nutrient Sources added to Food (ANS) was asked to provide a scientific opinion on the safety of stannic chloride added for nutritional purposes as a source of tin in food supplements and on the bioavailability of tin from this source.

The Panel notes that:

  • The dossier referred to stannic chloride (tin tetrachloride, CAS Register Number 7646-78-8) which is not the tin salt (stannous chloride or tin dichloride, CAS Register Number 7772-99-8) permitted as a food additive in Europe. Stannous chloride has been previously assessed by JECFA (1982 and 1988) and the SCF (1991). The Panel concluded that those evaluations were therefore not relevant to the dossier.
  • The Opinion of the Scientific Panel on Dietetic Products, Nutrition and Allergies (NDA), on a request from the Commission in 2005, related to the Tolerable Upper Intake Level of tin, had concluded that the available data from human and animal studies mostly dealing with tin dichloride, and not tin tetrachloride, were insufficient to derive a tolerable upper intake level for tin.
  • The petitioner has not provided any data on either the toxicity of stannic chloride or the bioavailability of tin from stannic chloride.
  • The limited existing toxicological data, specific to stannic chloride, have not been addressed by the petitioner.

Therefore, the Panel concludes that due to the lack of an appropriate dossier supporting the use of stannic chloride in food supplements, the safety of stannic chloride and the bioavailability of tin from this substance cannot be assessed.

Keywords
Food supplements, stannic chloride, tin tetrachloride, CAS number 7646-78-8