Scientific Opinion of the Scientific Panel on Plant Protection Products and their Residues (PPR Panel) on the genotoxic potential of triazine amine (metabolite common to several sulfonylurea active substances)

IN‐A4098, CGA 150 829, Aminotriazine, AE F059411, chromosome aberration, mutagenicity, residue, groundwater, pesticide
First published in the EFSA Journal
9 March 2020
Adopted
12 February 2020
Type
Scientific Opinion

Abstract

The Panel received a mandate from the European Commission to assess the genotoxic potential of triazine amine based on available information submitted by the applicants. Available information includes experimental genotoxicity data on triazine amine, Quantitative Structure–Activity Relationship (QSAR) analysis and read across with structurally similar compounds. Based on the overall weight of evidence, the Panel, in agreement with the cross‐cutting Working Group Genotoxicity, concluded that there is no concern for the potential of triazine amine to induce gene mutations and clastogenicity; however, the potential to induce aneugenicity was not adequately investigated. For a conclusion, an in vitro micronucleus assay performed with triazine amine would be needed.

Panel on Plant Protection Products and their Residues
Contact
pesticides.ppr [at] efsa.europa.eu
doi
10.2903/j.efsa.2020.6053
EFSA Journal 2020;18(3):6053
Question Number
On request from
European Commission