Safety of hexamethylene tetramine for pigs, poultry, bovines, sheep, goats, rabbits and horses

Hexamethylene tetramine, technological additive, silage additive, safety
First published in the EFSA Journal
14 February 2020
Adopted
28 January 2020
Type
Scientific Opinion

Abstract

Following a request from the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver a scientific opinion on hexamethylene tetramine (HMTA) for pigs, poultry, bovines, sheep, goats, rabbits and horses. In 2015, the FEEDAP Panel delivered an opinion on the safety and efficacy of HMTA. In that opinion, the Panel noted that the residues of HMTA in the silage amounted to about 5% of the inclusion level of 600 mg HMTA/kg fresh ensiling material. Since the HMTA residues in silage were analysed as formaldehyde, it was not possible to quantify the contribution of formaldehyde and HMTA to the residues. In the absence of a qualitative and quantitative characterisation of the residues, the Panel could not conclude on the safety of HMTA for the target species. Based on the results of a new study in which HMTA was measured in silage, the concentration of HMTA dropped below the limit of quantification of 6 mg HMTA/kg silage, which corresponds to ~ 1% of the HMTA inclusion level in the fresh ensiling material. However, the formaldehyde concentration was not analysed in the silage. In the absence of a qualitative and quantitative characterisation of the residues, the Panel cannot conclude on the safety of HMTA for the target species.

Substances
Hexamethylene tetramine
Cas: 100-97-0
Inchi: InChI=1S/C6H12N4/c1-7-2-9-4-8(1)5-10(3-7)6-9/h1-6H2
Iupac: 1,3,5,7-tetraazatricyclo[3.3.1.1]-decane
Panel on Additives and Products or Substances used in Animal Feed
Contact
feedap [at] efsa.europa.eu
doi
10.2903/j.efsa.2020.6012
EFSA Journal 2020;18(2):6012
Question Number
On request from
European Commission