Lactobacillus plantarum 299v and non-haem iron absorption

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Article
Lactobacillus plantarum 299v;non-haem iron;absorption;health claim
First published in the EFSA Journal
25 July 2016
Adopted
28 June 2016
Type
Scientific Opinion
Abstract

Following an application from Probi AB submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Sweden, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA) was asked to deliver an opinion on the scientific substantiation of a health claim related to Lactobacillus plantarum 299v and an increase of non-haem iron absorption. The food that is the subject of the health claim is ‘Lactobacillus plantarum 299v (Lp299v)’. The Panel considers that Lp299v is sufficiently characterised. The claimed effect proposed by the applicant is ‘increase of non-haem iron absorption’. The target population proposed by the applicant is ‘healthy adults who want to increase their iron uptake’. The Panel considers that increasing non-haem iron absorption is a beneficial physiological effect. In weighing the evidence, the Panel took into account that the results of two double-blind, placebo-controlled, cross-over studies are inconsistent, as one study with some methodological limitations showed a positive effect of Lp299v on non-haem absorption, whereas the other did not show an effect. The Panel noted that among four single-blind, placebo-controlled, sequential studies at risk of systematic bias, three studies showed a positive effect of Lp299v on non-haem absorption and one did not show an effect. The Panel also took into account that there is no evidence for a plausible mechanism by which Lp299v could increase non-haem iron absorption in vivo in humans. The Panel concludes that the scientific evidence is insufficient to establish a cause and effect relationship between the consumption of Lp299v and an increase of non-haem iron absorption.

Panel members at the time of adoption
Jean-Louis Bresson, Barbara Burlingame, Tara Dean, Susan Fairweather-Tait, Marina Heinonen, Karen Ildico Hirsch-Ernst, Inge Mangelsdorf, Harry McArdle, Androniki Naska, Monika Neuhäuser-Berthold, Grażyna Nowicka, Kristina Pentieva, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Daniel Tomé, Dominique Turck, Hendrik Van Loveren, Marco Vinceti and Peter Willatts
Panel on Dietetic Products, Nutrition and Allergies
Contact
nda [at] efsa.europa.eu
doi
10.2903/j.efsa.2016.4550
EFSA Journal 2016;14(7):4550 [12 pp.].
Question Number
On request from
Competent Authority of Sweden following an application by Probi AB
Competing interests
In line with EFSA's policy on declarations of interest, Panel member Anders Sjödin did not participate in the development and adoption of this scientific opinion.
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Number of Pages
12