Identification of the substances from the Carcinogenic Potency Database (CPDB) which are of particular concern even if ingested at doses below 0.0025 µg/kg body weight per day

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Article
Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
EFSA Journal
EFSA Journal 2016;14(3):4407 [11 pp.].
doi
10.2903/j.efsa.2016.4407
Panel members at the time of adoption
Claudia Bolognesi, Laurence Castle, Jean-Pierre Cravedi, Karl-Heinz Engel, Paul Fowler, Roland Franz, Konrad Grob, Rainer Gürtler, Trine Husøy, Sirpa Kärenlampi, Wim Mennes, Maria Rosaria Milana, André Penninks, Vittorio Silano, Andrew Smith, Maria de Fátima Tavares Poças, Christina Tlustos, Detlef Wölfle, Holger Zorn and Corina-Aurelia Zugravu.
Acknowledgements

The Panel wishes to thank the members of the Working Group on Food Contact Materials: Claudia Bolognesi, Laurence Castle, Trine Husøy, Maria Rosaria Milana and Vittorio Silano, for the preparatory work on this scientific output and the hearing expert: Josef Schlatter and EFSA staff members: Anna F Castoldi and Rositsa Serafimova for the support provided to this scientific output.

Contact
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2015-00238
Adopted
9 February 2016
Approved
1 March 2016
Published
1 March 2016
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
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Abstract

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) was asked by the European Commission to supply information to supplement the EFSA 2015 opinion on high-density polyethylene (HDPE) recycling processes in a step-wise manner. The Terms of Reference required to supply a list of substances for which the most severe exposure threshold is applicable and to consider Table 1 column 1 in the 2004 study by Kroes et al. which lists categories of substances for which this threshold is not applicable. The CEF Panel concludes that it is not possible to provide an exhaustive list of substances ‘for which the most severe exposure threshold is applicable’ as such a list would have to be established based on all known substances, excepting a comparatively small number of substances excluded by the criteria in the approach taken. The CEF Panel has analysed the most recent Carcinogenic Potency Database consisting of 1,547 substances, and identified and listed those substances which are of particular concern even if ingested at, or below an intake level of 0.0025 µg/kg body weight per day, following the approach taken by the 2004 study by Kroes et al. The CEF Panel emphasises that this opinion does not impact the risk assessment approach taken in the opinion, adopted in February 2015, on processes producing recycled HDPE for use as a food contact material, or its conclusions.

Keywords
Carcinogenic potency, exposure threshold, TD50
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Number of Pages
11