Safety and efficacy of guanidinoacetic acid for chickens for fattening, breeder hens and roosters, and pigs

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Article
Panel on Additives and Products or Substances used in Animal Feed
EFSA Journal
EFSA Journal 2016;14(2):4394 [39 pp.].
doi
10.2903/j.efsa.2016.4394
Panel members at the time of adoption
Gabriele Aquilina, Giovanna Azimonti, Vasileios Bampidis, Maria de Lourdes Bastos, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Gerhard Flachowsky, Jürgen Gropp, Boris Kolar, Maryline Kouba, Secundino López Puente, Marta López-Alonso, Alberto Mantovani, Baltasar Mayo, Fernando Ramos, Guido Rychen, Maria Saarela, Roberto Edoardo Villa, Robert John Wallace and Pieter Wester
Acknowledgements
The Panel wishes to thank the members of the Working Group on Amino Acids and Vitamins including Lucio Costa, Noël Dierick and Lubomir Leng; as well as the former members of the Working Group on Amino Acids, Paul Brantom and Giovanna Martelli, for the preparatory work on this scientific opinion and EFSA staff member Jordi Tarrés-Call for the support provided to this scientific opinion.
Contact
feedap@efsa.europa.eu
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2012-00273
Adopted
27 January 2016
Published in the EFSA Journal
22 February 2016
Last Updated
27 October 2016. This version replaces the previous one/s.
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

Guanidinoacetic acid (GAA) occurs naturally in the body of animals (and humans) and acts as a precursor of creatine. The safe level of the product appears to be correlated with the supply of methyl donors. If an adequate supply of methyl donors is provided in the feed, a safe level of 1,200 mg GAA/kg complete feed could be established for chickens for fattening and piglets. The conclusion on piglets can be extended to pigs for fattening. In the absence of adequate data, the FEEDAP Panel cannot conclude on the safety of GAA for breeder hens and roosters. GAA is not mutagenic. The effects reported in the 28- and 90-day studies do not identify any unexpected toxicity other than physiological effects. Feeding GAA would not result in GAA, creatine or homocysteine concentrations in chicken and pig tissues/organs relevant to consumer safety provided the maximum GAA concentrations in feed considered safe are respected. GAA is not an irritant to eyes and skin and not a dermal sensitiser. Significant inhalation exposure may occur. However, due to the absence of data on respiratory toxicity, no risk assessment can be performed. The use of GAA in animal nutrition is not expected to pose a risk to the environment. Considering the data previously assessed and the two new studies, the FEEDAP Panel concludes that GAA is able to improve the performance in chickens for fattening at the minimum dose of 600 mg/kg. In the absence of adequate data, the FEEDAP Panel cannot conclude on the efficacy of GAA in breeder hens and roosters. In piglets, only one study was available showing that 1,200 mg GAA/kg complete feed improved growth. Therefore, the FEEDAP Panel is not in a position to conclude on the efficacy of GAA in this species.

Keywords
nutritional additive, guanidinoacetic acid, CreAMINO, safety, efficacy, homocysteine, chicken, pig
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Number of Pages
39