Scientific Opinion on the safety and efficacy of Liderfeed® (eugenol) for chickens for fattening

Liderfeed®, eugenol, zootechnical, feed additive, chickens for fattening, safety, efficacy
First published in the EFSA Journal
11 November 2015
21 October 2015
Last Updated
8 December 2017. This version replaces the previous one/s.
Scientific Opinion


Liderfeed® is a zootechnical feed additive containing eugenol as active ingredient with some excipients. It has not been authorised in the European Union for use in food or feed. Liderfeed® was initially formulated with clove oil as a source of eugenol. The applicant replaced the clove oil with purified eugenol at the same concentration as in the original formulation. The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) considered that studies carried out using the original formulation and the subsequently modified formulation are equivalent. The FEEDAP Panel concluded that Liderfeed® is safe for chickens for fattening at the proposed dose of 100 mg/kg complete feed. The addition of Liderfeed® at the recommended dose did not result in measurable concentrations of eugenol and its glucurono- and sulpho-conjugates in edible tissues. Liderfeed® is therefore considered safe for the consumer when used as an additive in feed for chickens for fattening. Liderfeed® is not considered to be a skin/eye irritant or a skin sensitiser. The exposure of users by inhalation is expected to be low. The use of Liderfeed® in feed for chickens for fattening can be considered safe for the environment. As only two out of the three efficacy studies showed a significant effect on the performance of chickens for fattening as a result of the supplementation with the additive, the FEEDAP Panel was unable to conclude on the efficacy of Liderfeed® in chickens for fattening. Dietary supplementation with Liderfeed® did not adversely affect chicken meat quality.

Panel members at the time of adoption

Gabriele Aquilina, Vasileios Bampidis, Maria de Lourdes Bastos, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Gerhard Flachowsky, Jürgen Gropp, Boris Kolar, Maryline Kouba, Secundino López Puente, Marta López-Alonso, Alberto Mantovani, Baltasar Mayo, Fernando Ramos, Guido Rychen, Maria Saarela, Roberto Edoardo Villa, Robert John Wallace and Pieter Wester.
Panel on Additives and Products or Substances used in Animal Feed
EFSA Journal 2015;13(11):4273
Question Number
On request from
European Commission