Scientific Opinion on Flavouring Group Evaluation 210 Revision 2 (FGE.210Rev2): Consideration of genotoxic potential for α,β-unsaturated alicyclic ketones and precursors from chemical subgroup 2.4 of FGE.19

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Article
Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
Acknowledgements

The Panel wishes to thank the members of the Working Group on Genotoxicity: Mona-Lise Binderup, Claudia Bolognesi, Riccardo Crebelli, Rainer Gürtler, Natália Kovalkovičová, Francesca Marcon, Daniel Marzin and Pasquale Mosesso, for the preparatory work on this scientific output and the hearing experts: Vibe Beltoft and Karin Nørby and EFSA staff members: Annamaria Rossi, Maria Carfi and Maria Anastassiadou for the support provided to this scientific output.

EFSA Journal
EFSA Journal 2015;13(7):4172 [33 pp.].
doi
10.2903/j.efsa.2015.4172
Panel members at the time of adoption
Claudia Bolognesi, Laurence Castle, Jean-Pierre Cravedi, Karl-Heinz Engel, Paul Fowler, Konrad Grob, Rainer Gürtler, Trine Husøy, Wim Mennes, Maria Rosaria Milana, André Penninks, Maria de Fátima Tavares Poças, Vittorio Silano, Andrew Smith, Christina Tlustos, Fidel Toldra, Detlef Wölfle and Holger Zorn.
Contact
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2015-00060
Adopted
24 June 2015
Published
10 July 2015
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

Safety Authority was requested to evaluate the genotoxic potential of 14 flavouring substances in Flavouring Group Evaluation 210 (FGE.210). In FGE.210, the Panel concluded that the genotoxic potential could not be ruled out for any of the flavouring substances. In FGE.210 Revision1, the Panel concluded that the concern for genotoxic potential is ruled out for eight substances [FL-no: 02.105, 07.007, 07.009, 07.011, 07.036, 07.088, 07.091 and 07.170] while for allyl a-ionone [FL-no: 07.061], for a-damascone [FL-no: 07.134] and four structurally related substances [FL-no: 07.130, 07.225, 07.226 and 07.231] the concern for genotoxicity remains and additional data were requested. The Flavour Industry has submitted additional genotoxicity data for allyl a-ionone [FL-no: 07.061], that are evaluated in the present revision of FGE.210 (Revision 2). Based on these new data the Panel concluded that the genotoxicity concern for allyl a-ionone [FL-no: 07.061] can be ruled out. For a-damascone [FL-no: 07.134] and the four structurally related substances [FL-no: 07.130, 07.225, 07.226 and 07.231] additional genotoxicity data are still required.

Keywords
α,β-unsaturated alicyclic ketones, flavouring substances, safety evaluation, FGE.210, subgroup 2.4, FGE.19
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Number of Pages
33