Scientific Opinion on Flavouring Group Evaluation 65, Revision 1 (FGE.65Rev1): Consideration of sulfur-substituted furan derivatives used as flavouring agents evaluated by JECFA (59th meeting) structurally related to a subgroup of substances within the group of ‘Furfuryl and furan derivatives with and without additional side-chain substituents and heteroatoms from chemical group 14’ evaluated by EFSA in FGE.13Rev2 (2011)


Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
EFSA Journal
EFSA Journal 2015;13(2):4024 [44 pp.].
Panel members at the time of adoption
Claudia Bolognesi, Laurence Castle, Jean-Pierre Cravedi, Karl-Heinz Engel, Paul Fowler, Roland Franz, Konrad Grob, Rainer Gürtler, Trine Husøy, Wim Mennes, Maria Rosaria Milana, André Penninks, Maria de Fatima Tavares Poças, Vittorio Silano, Andrew Smith, Christina Tlustos, Fidel Toldra, Detlef Wölfle and Holger Zorn.

The Panel wishes to thank the members of the Working Groups on Flavourings: Ulla Beckman Sundh, Leon Brimer, Karl-Heinz Engel, Rainer Gürtler, Trine Husøy, Wim Mennes, Gerard Mulder and Harriet Wallin for the preparatory work on this scientific opinion and the hearing experts: Vibe Beltoft and Karin Nørby and EFSA staff, Annamaria Rossi, Maria Carfi, Kim Rygaard Nielsen and Maria Anastassiadou for the support provided to this scientific opinion.

Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
29 January 2015
Published in the EFSA Journal
18 February 2015
European Food Safety Authority (EFSA), Parma, Italy

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to consider evaluations of flavouring substances assessed since 2000 by the Joint FAO/WHO Expert Committee on Food Additives (the JECFA), and to decide whether further evaluation is necessary, as laid down in Commission Regulation (EC) No 1565/2000. The substances are evaluated through a stepwise approach that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. FGE.65 concerns a group of 33 sulfur-substituted furan derivatives evaluated by the JECFA at their 59th meeting. The Panel concluded in FGE.65 that the evaluation could not be finalised for four of the 33 substances [FL-no: 13.056, 13.160, 13.193 and 13.194] due to lack of toxicity data. In the present revision of FGE.65, the toxicity data requested in FGE.65 for [FL-no: 13.160] have now become available. These toxicity data are also considered to cover the evaluation of [FL-no: 13.193 and 13.194], but not [FL-no: 13.056]. Based on the new data the Panel agrees with the JECFA conclusion, ‘No safety concern at estimated levels of intake as flavouring substances’ based on the MSDI approach for 32 of the furan derivatives. For one substance [FL-no: 13.056] a request for additional toxicity data still remains. Besides the safety assessment of these flavouring substances, the specifications for the materials of commerce have also been considered and for all 33 substances, the information is adequate.

sulfur-substituted furan derivatives, JECFA 59th meeting, FGE.65Rev1, FGE.13Rev2
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