Scientific Opinion on Dietary Reference Values for zinc

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Article
Panel on Dietetic Products, Nutrition and Allergies
EFSA Journal
EFSA Journal 2014;12(10):3844 [76 pp.].
doi
10.2903/j.efsa.2014.3844
Panel members at the time of adoption
Carlo Agostoni, Roberto Berni Canani, Susan Fairweather-Tait, Marina Heinonen, Hannu Korhonen, Sébastien La Vieille, Rosangela Marchelli, Ambroise Martin, Androniki Naska, Monika Neuhäuser-Berthold, Grażyna Nowicka, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Sean (J.J.) Strain, Inge Tetens, Daniel Tomé, Dominique Turck and Hans Verhagen.
Acknowledgements

The Panel wishes to thank the members of the Working Group on Dietary Reference Values for minerals: Peter Aggett, Carlo Agostoni, Susan Fairweather-Tait, Marianne Geleijnse, Michael Hambidge, Ambroise Martin, Androniki Naska, Hildegard Przyrembel and Alfonso Siani for the preparatory work on this scientific opinion, the hearing expert: Leland Miller, and EFSA staff: Anja Brönstrup, Fanny Héraud, Sofia Ioannidou, Laura Martino and Liisa Valsta for the support provided to this scientific opinion.

Contact
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2011-01233
Adopted
19 September 2014
Published in the EFSA Journal
10 October 2014
Last Updated
20 May 2015. This version replaces the previous one/s.
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values for zinc, using a two-stage factorial approach and reference values for body weight. The first stage of estimating physiological requirements used studies that had physiologically plausible data, specifically related to faecal excretion of endogenous zinc. Adult physiological requirements were closely related to body size, and sex differences were not detectable after adjustment for body weight. Average Requirements (ARs) for dietary zinc necessary to meet physiological requirements were estimated using saturation response modelling, taking into account the inhibitory effect of dietary phytate on zinc absorption. Estimated ARs and Population Reference Intakes (PRIs) are provided for phytate intake levels of 300, 600, 900 and 1 200 mg/day, which cover the range of mean/median intakes observed in European populations. ARs range from 6.2 to 10.2 mg/day for women with a reference weight of 58.5 kg and from 7.5 to 12.7 mg/day for men with a reference weight of 68.1 kg. PRIs were derived from the zinc requirement of individuals with a body weight at the 97.5th percentile for reference weights for men and women and range from 7.5 to 12.7 mg/day for women and from 9.4 to 16.3 mg/day for men. ARs for infants from seven months of age and for children were estimated factorially, based on extrapolation from estimates of adult losses plus zinc needs for growth, and range from 2.4 to 11.8 mg/day. PRIs for infants and children were derived by assuming a coefficient of variation of 10 %, and range from 2.9 to 14.2 mg/day. For pregnancy and lactation, additional zinc requirements related to fetal and maternal tissues and transfer of zinc into breast milk, respectively, were considered and additional PRIs of 1.6 and 2.9 mg/day, respectively, were estimated.

Keywords
zinc, Dietary Reference Value, Population Reference Intake, phytate
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Number of Pages
76