Scientific Opinion on Flavouring Group Evaluation 200 (FGE.200): 74 α,β-unsaturated aldehydes and precursors from subgroup 1.1.1 of FGE.19

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Article
Acknowledgements

The Panel wishes to thank the members of the Genotoxicity Working Group on Flavourings: Mona-Lise Binderup, Claudia Bolognesi, Angelo Carere, Riccardo Crebelli, Rainer Gürtler, Natália Kovalkovičová, Daniel Marzin and Pasquale Mosesso for the preparatory work on this scientific opinion and the hearing experts: Vibe Beltoft, Pia Lund and Karin Nørby and EFSA staff: Maria Carfi, Kim Rygaard Nielsen and Annamaria Rossi for the support provided to this scientific opinion.

Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
EFSA Journal
EFSA Journal 2014;12(6):3709 [57 pp.].
doi
10.2903/j.efsa.2014.3709
Panel members at the time of adoption
Ulla Beckman Sundh, Mona-Lise Binderup, Claudia Bolognesi, Leon Brimer, Laurence Castle, Alessandro Di Domenico, Karl-Heinz Engel, Roland Franz, Nathalie Gontard, Rainer Gürtler, Trine Husøy, Klaus-Dieter Jany, Martine Kolf-Clauw, Wim Mennes, Maria Rosaria Milana, Iona Pratt †, Kettil Svensson, Maria de Fátima Tavares Poças, Fidel Toldra and Detlef Wölfle.
Contact
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2013-00445
EFSA-Q-2013-00446
EFSA-Q-2013-00447
EFSA-Q-2013-00448
EFSA-Q-2013-00449
EFSA-Q-2013-00450
EFSA-Q-2013-00451
EFSA-Q-2013-00452
EFSA-Q-2013-00453
EFSA-Q-2013-00454
EFSA-Q-2013-00455
EFSA-Q-2013-00456
EFSA-Q-2013-00457
EFSA-Q-2013-00458
EFSA-Q-2013-00459
EFSA-Q-2013-00460
EFSA-Q-2013-00461
EFSA-Q-2013-00462
EFSA-Q-2013-00463
EFSA-Q-2013-00464
EFSA-Q-2013-00465
EFSA-Q-2013-00466
EFSA-Q-2013-00467
EFSA-Q-2013-00468
EFSA-Q-2013-00469
EFSA-Q-2013-00470
EFSA-Q-2013-00471
EFSA-Q-2013-00472
EFSA-Q-2013-00473
EFSA-Q-2013-00474
EFSA-Q-2013-00475
EFSA-Q-2013-00476
EFSA-Q-2013-00477
EFSA-Q-2013-00478
EFSA-Q-2013-00479
EFSA-Q-2013-00480
EFSA-Q-2013-00481
EFSA-Q-2013-00482
EFSA-Q-2013-00483
EFSA-Q-2013-00484
EFSA-Q-2013-00485
EFSA-Q-2013-00486
EFSA-Q-2013-00487
EFSA-Q-2013-00488
EFSA-Q-2013-00489
EFSA-Q-2013-00490
EFSA-Q-2013-00491
EFSA-Q-2013-00492
EFSA-Q-2013-00493
EFSA-Q-2013-00494
EFSA-Q-2013-00495
EFSA-Q-2013-00496
EFSA-Q-2013-00497
EFSA-Q-2013-00498
EFSA-Q-2013-00499
EFSA-Q-2013-00500
EFSA-Q-2013-00501
EFSA-Q-2013-00502
EFSA-Q-2013-00503
EFSA-Q-2013-00504
EFSA-Q-2013-00505
EFSA-Q-2013-00506
EFSA-Q-2013-00507
EFSA-Q-2013-00508
EFSA-Q-2013-00509
EFSA-Q-2013-00510
EFSA-Q-2013-00511
EFSA-Q-2013-00512
EFSA-Q-2013-00513
EFSA-Q-2013-00514
EFSA-Q-2013-00515
EFSA-Q-2013-00516
EFSA-Q-2013-00517
EFSA-Q-2013-00518
Adopted
21 May 2014
Published
12 June 2014
Last Updated
4 August 2014. This version replaces the previous one/s.
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate the genotoxic potential of 74 flavouring substances from subgroup 1.1.1 of FGE.19 in the Flavouring Group Evaluation 200 (FGE.200). The Flavour Industry has provided additional genotoxicity studies for one representative substance in FGE.200, namely hex-2(trans)-enal [FL-no 05.073], and for other two substances in the same subgroup, namely 2-dodecenal [05.037] and 2-nonenal [05.171]. The Panel has evaluated these data and concluded that the concern still remains with respect to genotoxicity for the substances of this subgroup and their three representative substances. The Panel confirms, the need for an in vivo Comet assay performed in duodenum and liver for hex-2(trans)-enal [FL-no: 05.073]. For the two other representative substances of subgroup 1.1.1 (nona-2(trans),6(cis)-dienal [FL-no: 05.058] and oct-2-enal [FL-no: 05.060]), a combined in vivo Comet assay and micronucleus assay would be required. For the latter, evidence of bone marrow exposure should be provided.

Keywords
α,β-unsaturated aldehydes, straight chain, FGE.200, flavouring substances, safety evaluation, subgroup 1.1.1, FGE.19
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Number of Pages
57