Scientific Opinion on Flavouring Group Evaluation 401 (FGE.401): γ-Glutamyl-valyl-glycine from chemical group 34


Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
EFSA Journal
EFSA Journal 2014;12(4):3625 [34 pp.].
Panel Members
Ulla Beckman Sundh, Mona-Lise Binderup, Claudia Bolognesi, Leon Brimer, Laurence Castle, Alessandro Di Domenco, Karl-Heinz Engel, Roland Franz, Nathalie Gontard, Rainer Gürtler, Trine Husøy, Klaus-Dieter Jany, Martine Kolf-Clauw, Wim Mennes, Maria Rosaria Milana, Iona Pratt †, Kettil Svensson, Maria de Fátima Tavares Poças, Fidel Toldrá and Detlef Wölfle

The Panel wishes to thank the members of the Working Group on Flavourings: Ulla Beckman Sundh, Leon Brimer, Angelo Carere, Karl-Heinz Engel, Henrik Frandsen, Rainer Gürtler, Frances Hill, Trine Husøy, Wim Mennes, Gerard Mulder and Harriet Wallin for the preparatory work on this scientific opinion and the hearing experts: Vibe Beltoft, Pia Lund and Karin Nørby and EFSA’s staff member : Maria Carfí, Annamaria Rossi and Kim Rygaard Nielsen for the support provided to this scientific opinion.

Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
27 March 2014
Published in the EFSA Journal
10 April 2014
European Food Safety Authority (EFSA), Parma, Italy

The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to carry out a safety assessment of one flavouring substance, γ-glutamyl-valyl-glycine [FL-no: 17.038], in the Flavouring Group Evaluation 401 (FGE.401), in accordance with the Commission Regulation (EC) No 1331/2008. There is no safety concern with respect to genotoxicity for the flavouring substance. It has been demonstrated that the flavouring substance, which is a tripeptide, will be hydrolysed to the three amino acids L-glutamic acid, L-valine and glycine. As the human consumption of these three endogenous amino acids through food is orders of magnitude higher than the anticipated levels of exposure from their use as flavouring substances, the Panel concluded that γ-glutamyl-valyl-glycine [FL-no: 17.038] would be of no safety concern at its estimated level of intake as flavouring substance. The specifications for γ-glutamyl-valyl-glycine [FL-no: 17.038] are considered adequate according to Commission Regulation (EC) no 1334/2008.

food safety, flavouring, γ-glutamyl-valyl-glycine, [FL-no: 17.038], CASrn 38837-70-6
Print on demand
Number of Pages