Scientific Opinion on Flavouring Group Evaluation 401 (FGE.401): γ-Glutamyl-valyl-glycine from chemical group 34

food safety, flavouring, γ-glutamyl-valyl-glycine, [FL-no: 17.038], CASrn 38837-70-6
First published in the EFSA Journal
10 April 2014
27 March 2014
Scientific Opinion


The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to carry out a safety assessment of one flavouring substance, γ-glutamyl-valyl-glycine [FL-no: 17.038], in the Flavouring Group Evaluation 401 (FGE.401), in accordance with the Commission Regulation (EC) No 1331/2008. There is no safety concern with respect to genotoxicity for the flavouring substance. It has been demonstrated that the flavouring substance, which is a tripeptide, will be hydrolysed to the three amino acids L-glutamic acid, L-valine and glycine. As the human consumption of these three endogenous amino acids through food is orders of magnitude higher than the anticipated levels of exposure from their use as flavouring substances, the Panel concluded that γ-glutamyl-valyl-glycine [FL-no: 17.038] would be of no safety concern at its estimated level of intake as flavouring substance. The specifications for γ-glutamyl-valyl-glycine [FL-no: 17.038] are considered adequate according to Commission Regulation (EC) no 1334/2008.

Panel members at the time of adoption

Ulla Beckman Sundh, Mona-Lise Binderup, Claudia Bolognesi, Leon Brimer, Laurence Castle, Alessandro Di Domenco, Karl-Heinz Engel, Roland Franz, Nathalie Gontard, Rainer Gürtler, Trine Husøy, Klaus-Dieter Jany, Martine Kolf-Clauw, Wim Mennes, Maria Rosaria Milana, Iona Pratt †, Kettil Svensson, Maria de Fátima Tavares Poças, Fidel Toldrá and Detlef Wölfle
Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
cef [at]
EFSA Journal 2014;12(4):3625
Question Number
On request from
European Commission