Scientific Opinion on Dietary Reference Values for vitamin C


Panel on Dietetic Products, Nutrition and Allergies
EFSA Journal
EFSA Journal 2013;11(11):3418 [68 pp.].
Panel Members
Carlo Agostoni, Roberto Berni Canani, Susan Fairweather-Tait, Marina Heinonen, Hannu Korhonen, Sébastien La Vieille, Rosangela Marchelli, Ambroise Martin, Androniki Naska, Monika Neuhäuser-Berthold, Grażyna Nowicka, Yolanda Sanz, Alfonso Siani, Anders Sjödin, Martin Stern, Sean (J.J.) Strain, Inge Tetens, Daniel Tomé, Dominique Turck and Hans Verhagen

The Panel wishes to thank the members of the Working Group on Dietary Reference Values for vitamins: Monika Neuhäuser-Berthold, Grażyna Nowicka, Kristina Pentieva, Hildegard Przyrembel, Sean (J.J.) Strain, Inge Tetens, Daniel Tomé and Dominique Turck for the preparatory work on this scientific opinion and EFSA staff: Anja Brönstrup for the support provided to this scientific opinion.

Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
10 October 2013
Published in the EFSA Journal
4 November 2013
European Food Safety Authority (EFSA), Parma, Italy

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies (NDA) derived Dietary Reference Values (DRVs) for vitamin C. The Panel concludes that an Average Requirement (AR) can be derived from indicators of vitamin C status, as well as a Population Reference Intake (PRI) assuming a coefficient of variation (CV) of 10 %. Several health outcomes possibly associated with vitamin C intake were also considered but data were found to be insufficient to establish DRVs. For healthy adults, the AR is determined from the quantity of vitamin C that balances metabolic vitamin C losses and allows the maintenance of an adequate body pool characterised by fasting plasma ascorbate concentrations at around 50 µmol/L. In men, an AR of 90 mg/day of vitamin C and a PRI of 110 mg/day are proposed. As no value for metabolic losses is available in women, the AR for women is extrapolated from the AR for men on the basis of differences in reference body weight, and an AR of 80 mg/day and a PRI of 95 mg/day are proposed. For infants aged 7-11 months, the Panel has decided to retain the PRI of 20 mg/day set by the SCF (1993), as no suitable evidence has emerged since the previous assessment. For children and adolescents, the ARs for vitamin C are extrapolated from the ARs for adults taking into account differences in reference body weight, and PRIs are derived, ranging from 20 mg/day for 1 to 3 year-old children, to 100 and 90 mg/day for boys and girls aged
15-17 years, respectively. For pregnant and lactating women, vitamin C intakes of 10 mg/day and of 60 mg/day in addition to the PRI of non-pregnant non-lactating women are proposed.

vitamin C, metabolic losses, plasma ascorbate, average requirement, Dietary Reference Value, health outcomes
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