International Frameworks Dealing with Human Risk Assessment of Combined Exposure to Multiple Chemicals

Tabs

Article
risk assessment, human health, combined exposure, multiple chemicals, chemical mixtures, frameworks, methodology
First published in the EFSA Journal
12 July 2013
Approved
9 July 2013
Type
Scientific Report of EFSA
Abstract

The development of harmonised terminology and frameworks for the human risk assessment of combined exposure to multiple chemicals (“chemical mixtures”) is an important area for EFSA and a number of activities have already been undertaken, i.e. in the fields of pesticides and contaminants. The first step prior to a risk assessment of combined exposure to multiple chemicals is problem formulation defining the relevant exposure, hazard and population to be considered. In practice, risk assessment of multiple chemicals is conducted using a tiered approach for exposure assessment, hazard assessment and risk characterisation. Higher tiers require increasing knowledge about the group of chemicals under assessment and the tiers can range from tier 0 (default values, data poor situation) to tier 3 (full probabilistic models). This scientific report reviews the terminology, methodologies and frameworks developed by national and international agencies for the human risk assessment of combined exposure to multiple chemicals and provides recommendations for future activities at EFSA in this area.

doi
10.2903/j.efsa.2013.3313
EFSA Journal 2013;11(7):3313 [69 pp.].
Question Number
On request from
EFSA
European Food Safety Authority
Print on demand
Number of Pages
69