Revised exposure assessment for ethyl lauroyl arginate for the proposed uses as a food additive

Tabs

Article
European Food Safety Authority
Acknowledgements

EFSA wishes to thank the Food Ingredients & Packaging Unit, A. Tard, H. Kenigswald and the Dietary & Chemical Monitoring Unit, D. Arcella for the preparatory work on this scientific output and C. Tlustos and J.C. Leblanc for the support provided to this scientific output.

EFSA Journal
EFSA Journal 2012;10(4):2652 [14 pp.].
doi
10.2903/j.efsa.2012.2652
Contact
Type
Statement of EFSA
On request from
European Commission
Question Number
EFSA-Q-2011-00030
Approved
4 April 2012
Published
26 April 2012
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

Following a request from the European Commission, the European Food Safety Authority (EFSA), carried out a revised exposure assessment of ethyl lauroyl arginate (LAE) from its use as a food additive, for children and adults, based on the revised proposed uses presented in the terms of reference. Revised exposure estimates have been calculated with revised proposed use levels and individual food consumption data from the EFSA Comprehensive Database. When considering consumers only, the anticipated dietary exposure to LAE ranges from 0.06 to 0.50 mg/kg bw/day at the mean, and from 0.15 to 0.91 mg/kg bw/day at the 95th percentile. For high consumers (95th percentile), all population groups except the elderly, have an exposure above the ADI. The main contributor to the total anticipated dietary exposure to LAE is the category of heat-treated meat products. In 2011 by the SCCS estimated the systemic exposure to LAE resulting from its use in cosmetics around 0.0322 mg/kg bw/d. With the assumptions that oral exposure results in a corresponding systemic exposure to all released metabolites and that following dermal absorption and uptake into the circulation LAE will be rapidly and completely converted to the same metabolites as those generated following oral exposure, a comparison between the dietary exposure and the systemic exposure resulting from cosmetic products was made. This exposure is similar to the lowest range of the mean estimates from diet for the total population. For all populations, the additional exposure resulting from the use of LAE in cosmetics could be considered as minor compared to high level dietary exposure and would not change the status of the different population groups regarding the exceedance of the ADI.

Keywords
Ethyl lauroyl arginate, revised uses, revised use levels, exposure
Print on demand
Number of Pages
14