Scientific Opinion on the safety and efficacy of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group (chemical group 25) when used as flavourings for all species

Sensory Additives, Feed Flavourings, 2-methoxyphenol, thymol, 2-methoxy-4-methylphenol, 4-ethylguaiacol, 2-methoxy-4-vinylphenol, 4-ethylphenol, 3-methylphenol, 2-methylphenol, 4-methylphenol, carvacrol, 2,6-dimethoxyphenol, phenol, 2,6-dimethylphenol
First published in the EFSA Journal
15 February 2012
1 February 2012
Last Updated
29 February 2012. This version replaces the previous one/s.
Scientific Opinion


Chemical Group 25 (CG 25) consist of phenol derivatives containing ring-alkyl, ring-alkoxy and side-chains with an oxygenated functional group, of which 16 are currently authorised for use as flavours in food. The flavouring compounds are calculated to be safe for all animal species at a maximum level of 5 mg/kg complete feed. This value supports the highest proposed use level for 13 of the 16 compounds with the margin of safety of approximately 1 to 5 for pigs and poultry, the most sensitive species. This safe level is substantially below the maximum proposed use level for all species for thymol and carvacrol (125 mg/kg complete feed) and for 3-methoxyphenol (25 mg/kg complete feed). The Panel concludes that the use of any of the 16 compounds included in CG 25 at the maximum proposed use level in animal feed would not raise safety concerns for consumers of animal products. No new data on the safety for the user was provided. However, potential hazards for skin and eye contact and respiratory exposure of various severities are recognised for all of the compounds included in CG 25. The Panel expects that at the use level safe for all target species (5 mg/kg feed), the 16 compounds included in CG 25 do not pose a risk for the environment. Since all 16 compounds include in CG 25 are used in food as flavourings and their function in feed is essentially the same as that in food, no further demonstration of efficacy was considered necessary.

Panel members at the time of adoption

Gabriele Aquilina, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Joop de Knecht, Noël Albert Dierick, Mikolaj Antoni Gralak, Jürgen Gropp, Ingrid Halle, Christer Hogstrand, Reinhard Kroker, Lubomir Leng, Secundino López Puente, Anne-Katrine Lundebye Haldorsen, Alberto Mantovani, Giovanna Martelli, Miklós Mézes, Derek Renshaw, Maria Saarela, Kristen Sejrsen and Johannes Westendorf
Panel on Additives and Products or Substances used in Animal Feed
EFSA Journal 2012;10(2):2573
Question Number
On request from
European Commission