Scientific Opinion on the safety evaluation of the substance, dioctadecyl disulphide, CAS No 2500-88-1, for use in food contact materials


Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids
EFSA Journal
EFSA Journal 2011;9(10):2401 [9 pp.].
Possible conflict of interest
One member of the Panel, D. Wölfle, declared an interest as he prepared the summary of the toxicological data on the substance under contract of his Institute BfR with EFSA. This was considered as a conflict of interest because he could not act at the same time as a representative of the contractor and a member of the Panel with voting rights. He was allowed to stay in the room to answer questions specifically addressed to him but did not participate in the discussion of the opinion.
Panel Members
Arturo Anadón, Mona-Lise Binderup, Wilfried Bursch, Laurence Castle, Riccardo Crebelli, Karl-Heinz Engel, Roland Franz, Nathalie Gontard, Thomas Haertlé, Trine Husøy, Klaus-Dieter Jany, Catherine Leclercq, Jean-Claude Lhuguenot, Wim Mennes, Maria Rosaria Milana, Karla Pfaff, Kettil Svensson, Fidel Toldrá, Rosemary Waring, Detlef Wölfle

The Panel wishes to thank the members of the Working Group on Food Contact Materials for the preparation of this opinion: Mona-Lise Binderup, Laurence Castle, Riccardo Crebelli, Roland Franz, Nathalie Gontard, Eugenia Lampi, Jean-Claude Lhuguenot, Maria Rosaria Milana, Karla Pfaff, Kettil Svensson and Detlef Wölfle for the support provided to this EFSA scientific output.

Opinion of the Scientific Committee/Scientific Panel
On request from
DG SANCO, Brussels
Question Number
29 September 2011
Published in the EFSA Journal
12 October 2011
European Food Safety Authority (EFSA), Parma, Italy

This scientific opinion of EFSA deals with the safety assessment of the additive dioctadecyl disulphide, CAS No 2500-88-1, REF. No 49840; FCM substance No 449 for which the CEF Panel concluded that a limited daily intake of the substance up to 0.05 mg/person is unlikely to be a safety concern.

α-Dimethyl-3-(4'-hydroxy-3'-methoxyphenyl)propylsilyloxy,ω-3-dimethyl-3-(4'-hydroxy-3'-methoxyphenyl)propylsilyl polydimethylsiloxane, n=26-50; CAS number 156065-00-8; Ref. No. 16265; FCM substance No. 874; Eugenol, Food contact materials; Safety assessm
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