Scientific Opinion on Polybrominated Diphenyl Ethers (PBDEs) in Food

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Acknowledgements

The Panel wishes to thank the members of the Working Group on Brominated Flame Retardants in Food: Åke Bergman, Alan Raymond Boobis, Sandra Ceccatelli, Jean-Pierre Cravedi, Metka Filipič, Peter Fürst, Niklas Johansson, Helle Knutsen, Miroslav Machala, Franco Merletti, Olaf Päpke, Dieter Schrenk, Rolaf van Leeuwen, Stefan van Leeuwen and Marco Zeilmaker for the preparatory work on this scientific opinion and the hearing experts: Bas Bokkers and Catherine Viguié, and EFSA staff: Alessandro Carletti, Gina Cioacata, Luisa Ramos Bordajandi and Elena Scaravelli for the support provided to this scientific opinion. The CONTAM Panel acknowledges all the European countries that provided PBDEs occurrence data in food and supported the consumption data collection for the Comprehensive European Food Consumption Database.

Panel on Contaminants in the Food Chain
EFSA Journal
EFSA Journal 2011;9(5):2156 [274 pp.].
doi
10.2903/j.efsa.2011.2156
Panel members at the time of adoption
Jan Alexander, Diane Benford, Alan Raymond Boobis, Sandra Ceccatelli, Bruce Cottrill, Jean-Pierre Cravedi, Alessandro Di Domenico, Daniel Doerge, Eugenia Dogliotti, Lutz Edler, Peter Farmer, Metka Filipič, Johanna Fink-Gremmels, Peter Fürst, Thierry Guérin, Helle Katrine Knutsen, Miroslav Machala, Antonio Mutti, Martin Rose, Josef Rudolf Schlatter and Rolaf van Leeuwen
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2009-00684
Adopted
9 May 2011
Published
30 May 2011
Last Updated
4 August 2011. This version replaces the previous one/s.
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

EFSA was asked by the European Commission to deliver a scientific opinion on polybrominated diphenyl ethers (PBDEs) in food. PBDEs are additive flame retardants which are applied in plastics, textiles, electronic castings and circuitry. PBDEs are ubiquitously present in the environment and likewise in biota and in food and feed. Data from the analysis of 19 PBDE congeners in 3,971 food samples were provided to EFSA by 11 European countries. Eight congeners were considered by the Panel on Contaminants in the Food Chain (CONTAM Panel) to be of primary interest: BDE-28, -47, -99, -100, -153, -154, -183 and -209. The highest dietary exposure is to BDE-47 and -209. Toxicity studies were carried out with technical PBDE mixtures or individual congeners. Main targets were the liver, thyroid hormone homeostasis and the reproductive and nervous system. PBDEs cause DNA damage through the induction of reactive oxygen species. The Panel identified effects on neurodevelopment as the critical endpoint, and derived benchmark doses (BMDs) and their corresponding lower 95 % confidence limit for a benchmark response of 10 %, BMDL10s, for a number of PBDE congeners: BDE-47, 309 μg/kg b.w.; BDE-99, 12 μg/kg b.w.; BDE 153, 83 μg/kg b.w.; BDE-209, 1,700 μg/kg b.w. Due to the limitations and uncertainties in the current database, the Panel concluded that it was inappropriate to use these BMDLs to establish health based guidance values, and instead used a margin of exposure (MOE) approach for the health risk assessment. Since elimination characteristics of PBDE congeners in animals and humans differ considerably, the Panel used the body burden as starting point for the MOE approach. The CONTAM Panel concluded that for BDE-47, -153 and -209 current dietary exposure in the EU does not raise a health concern. For BDE-99 there is a potential health concern with respect to current dietary exposure.

Keywords
Polybrominated diphenyl ethers, PBDE, food, human exposure, body burden, kinetics, metabolism, toxicity, risk assessment, margin of exposure (MOE)
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Number of Pages
274