Comparison of the Approaches Taken by EFSA and JECFA to Establish a HBGV for Cadmium

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Article
Cadmium, meta-analysis, dose-response model, PK models, benchmark dose, hybrid approach
First published in the EFSA Journal
8 February 2011
Approved
7 February 2011
Last Updated
10 February 2011. This version replaces the previous one/s.
Type
Scientific Report of EFSA
Abstract

EFSA received a mandate from the European Commission (EC) to re-assess the elements linked to the establishment of the health-based guidance value in the opinion on cadmium in food of the EFSA’s CONTAM panel (EFSA, 2009a). The CONTAM Unit asked support from the Assessment Methodology Unit to re-assess the elements leading to the establishment of the health-based guidance value in the opinion taking into account a report established by the Joint FAO/WHO Expert Committee on Food Additives (JECFA, 2010) where a different health-based guidance value was concluded. In this scientific report, the methodology used by EFSA and its rationale is described in more detail, and supporting evidence for the need of an adjustment factor to establish a health-based guidance value is provided. A comparison between JECFA and EFSA approaches is presented, as well as a sensitivity analysis in relation to the choice of the toxicodynamic variability function used by JECFA in their approach, to illustrate impact when establishing a health-based guidance value.

Contact
amu [at] efsa.europa.eu
doi
10.2903/j.efsa.2011.2006
EFSA Journal 2011;9(2):2006 [28 pp.].
Question Number
On request from
EFSA
European Food Safety Authority
Print on demand
Number of Pages
28