Scientific Opinion on BSE/TSE infectivity in small ruminant tissues

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Article
Panel on Biological Hazards
Acknowledgements

The Panel wishes to thank the members of the Working Group on BSE/TSE infectivity in small ruminant tissues: Olivier Andreoletti, Sylvie Benestad, Bossers Alex, Christian Ducrot, Alexandre Fediaevsky, Christine Hoffmann, James Hope, Ciriaco Ligios and Marion Simmons for the preparatory work on this scientific opinion.

EFSA Journal
EFSA Journal 2010;8(12):1875 [92 pp.].
doi
10.2903/j.efsa.2010.1875
Panel members at the time of adoption
Olivier Andreoletti, Herbert Budka, Sava Buncic, John D Collins, John Griffin, Tine Hald, Arie Havelaar, James Hope, Günter Klein, James McLauchlin, Christine Müller-Graf, Christophe Nguyen-The, Birgit Noerrung, Luisa Peixe, Miguel Prieto Maradona, Antonia Ricci, John Sofos, John Threlfall, Ivar Vågsholm, Emmanuel Vanopdenbosch.
Type
Opinion of the Scientific Committee/Scientific Panel
On request from
European Commission
Question Number
EFSA-Q-2010-00052
Adopted
21 October 2010
Published
2 December 2010
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Abstract

The objectives addressed were i) to provide an update on TSE (Transmissible Spongiform Encephalopathy) infectivity distribution in small ruminant tissues; and ii) to indicate based on the current epidemiological situation as regards to BSE (Bovine Spongiform Encephalopathy) in the small ruminant population in the EU (European Union), whether a review of the existing SRM (Specified Risk Materials) list for small ruminants should be envisaged with regard to the potential exposure to the BSE agent. The appraisal was addressed by reviewing for Classical scrapie, BSE and Atypical scrapie in small ruminants aspects related to: i) tissue infectivity distribution according to the age and the genotype of sheep and goats; and ii) the infectious load in the different tissues. In order to perform the assessment all the currently available scientific results were reviewed, and data on TSE monitoring in small ruminants in the EU and on small ruminants slaughtered by species and age category in each EU Member State were considered. The reduction of the infectivity associated to the carcass of an infected individual achieved by the current SRM policy in small ruminants for Classical scrapie and BSE was estimated. The total number of Classical scrapie infected sheep and goats that could enter yearly into the food chain was provided. Moreover, considerations about Atypical scrapie were given. A set of simulations allowing estimating the impact of different policy options on the BSE infectious load potentially present in an infected sheep was provided.

Keywords
Bovine Spongiform Encephalopathy (BSE), Classical scrapie, Atypical scrapie, Transmissible Spongiform Encephalopathies (TSEs), Specified Risk Material (SRM), Small Ruminants
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Number of Pages
92