Scientific Opinion on the substantiation of a health claim related to thiamine and carbohydrate and energy-yielding metabolism pursuant to Article 14 of Regulation (EC) No 1924/2006

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Article
EFSA Journal 2010; 8(7):1690 [9 pp.].
doi
10.2903/j.efsa.2010.1690
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
Panel Members
Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Monika Neuhäuser-Berthold, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens, Daniel Tomé, Hendrik van Loveren, Verhagen
Acknowledgement

The Panel wishes to thank the members of the Working Group on Claims for the preparatory work on this opinion: Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Marina Heinonen, Hannu Korhonen, Martinus Løvik, Ambroise Martin, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Inge Tetens, Hendrik van Loveren and Hans Verhagen

Contact
Type
Opinion of the Scientific Committee/Scientific Panel
On Request From
IDACE
Question Number
EFSA-Q-2008-183
Adopted
9 July 2010
Published
22 July 2010
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Article (190.42 KB)190.42 KB
Abstract

Following an application from IDACE submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to thiamine and carbohydrate and energy-yielding metabolism. Thiamine is a well recognised nutrient and is measurable in foods by established methods. Thiamine is considered to be characterised. Normal carbohydrate and energy-yielding metabolism is considered to be a beneficial physiological effect. Four opinions of authoritative/scientific bodies and two review papers were identified by the applicant as being pertinent to the health claim, of which one review did not address the role of thiamine in carbohydrate and energy-yielding metabolism. It is well recognised, that thiamine pyrophosphate, the active form of thiamine, is a cofactor of several enzymes involved in energy-yielding, branched-chain amino acid and carbohydrate metabolism. The Panel concludes that a cause and effect relationship has been established between the dietary intake of thiamine and normal carbohydrate and energy-yielding metabolism. The following wording reflects the scientific evidence: “Thiamine contributes to normal carbohydrate and energy-yielding metabolism.” The target population is infants and children up to 18 years. © European Food Safety Authority, 2010.

Summary

Following an application from IDACE submitted pursuant to Article 14 of Regulation (EC) No 1924/2006 via the Competent Authority of France, the Panel on Dietetic Products, Nutrition and Allergies was asked to deliver an opinion on the scientific substantiation of a health claim related to thiamine and normal carbohydrate and energy-yielding metabolism.

The scope of the application was proposed to fall under a health claim referring to children’s development and health.

The food constituent that is the subject of the health claim is thiamine, which is a well recognised nutrient and is measurable in foods by established methods. The Panel considers that the food constituent, thiamine, which is the subject of the health claim, is sufficiently characterised.

The claimed effect is “vitamin B1 plays and important role in the carbohydrate and energy metabolism of food”. The proposed target population for the health claim is children from birth to three years. The Panel considers that normal carbohydrate and energy-yielding metabolism is a beneficial physiological effect.

The applicant provided four opinions of authoritative/scientific bodies and two review papers which were retrieved following a literature search in Pubmed. One of the reviews did not address the role of thiamine in carbohydrate and energy-yielding metabolism. The other review dealt with the role of B-vitamins in mitochondrial energy-yielding metabolism.

It is well recognised, that thiamine pyrophosphate, the active form of thiamine, is a cofactor of several enzymes involved in energy-yielding, branched-chain amino acid and carbohydrate metabolism.

On the basis of the data presented, the Panel concludes that a cause and effect relationship has been established between the dietary intake of thiamine and normal carbohydrate and energy-yielding metabolism.

The Panel considers that the following wording reflects the scientific evidence: “Thiamine contributes to normal carbohydrate and energy-yielding metabolism.”

The Panel considers that, in order to bear the claim, follow-on formulae should comply with the criteria of composition of follow-on formulae as laid down in Directive 2006/141/EC, nutritionally complete foods for special medical purposes intended for use by infants and nutritionally complete foods for special medical purposes other than those intended for use by infants should comply with the criteria of composition of these foods as laid down in Directive 1999/21/EC, processed cereal-based foods for infants and young children should comply with the criteria of composition of these foods as laid down in Directive 2006/125/EC, other foodstuffs intended for infants and young children should provide at least 15 % of the reference values for nutrition labelling for foods intended for infants and young children as laid down in Directive 2006/125/EC, all other foodstuffs should be at least a source of thiamine as per Annex to Regulation (EC) No 1924/2006. Such amounts can be easily consumed as part of a balanced diet. The target population is infants and children up to 18 years.
 

Keywords
Thiamine, infants, children, carbohydrates, energy-yielding metabolism, health claim
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Number of Pages
9