Scientific Opinion on the substantiation of health claims related to various food(s)/food constituent(s) and protection of cells from premature aging, antioxidant activity, antioxidant content and antioxidant properties, and protection of DNA, proteins

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Article
EFSA Journal 2010; 8(2):1489 [63 pp.].
doi
10.2903/j.efsa.2010.1489
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA)
Panel Members
Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Hannu Korhonen, Pagona Lagiou, Martinus Løvik, Rosangela Marchelli, Ambroise Martin, Bevan Moseley, Monika Neuhäuser-Berthold, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Stephan Strobel, Inge Tetens, Daniel Tomé, Hendrik van Loveren and Hans Verhagen.
Acknowledgement

The Panel wishes to thank for the preparation of this opinion: The members of the Working Group on Claims: Carlo Agostoni, Jean-Louis Bresson, Susan Fairweather-Tait, Albert Flynn, Ines Golly, Marina Heinonen, Hannu Korhonen, Martinus Løvik, Ambroise Martin, Hildegard Przyrembel, Seppo Salminen, Yolanda Sanz, Sean (J.J.) Strain, Inge Tetens, Hendrik van Loveren and Hans Verhagen. The members of the Claims Sub-Working Group on Cardiovascular Health/Oxidative Stress: Antti Aro, Marianne Geleijnse, Marina Heinonen, Ambroise Martin, Wilhelm Stahl and Henk van den Berg.

Contact
Type
Opinion of the Scientific Committee/Scientific Panel
On Request From
European Commission
Question Number
EFSA-Q-2008-1357
EFSA-Q-2008-1939
EFSA-Q-2008-1967
EFSA-Q-2008-1981
EFSA-Q-2008-1994
EFSA-Q-2008-1995
EFSA-Q-2008-1996
EFSA-Q-2008-1998
EFSA-Q-2008-2023
EFSA-Q-2008-2052
EFSA-Q-2008-2058
EFSA-Q-2008-2104
EFSA-Q-2008-2176
EFSA-Q-2008-2182
EFSA-Q-2008-2205
EFSA-Q-2008-2415
EFSA-Q-2008-2442
EFSA-Q-2008-2530
EFSA-Q-2008-2538
EFSA-Q-2008-2541
EFSA-Q-2008-2566
EFSA-Q-2008-2583
EFSA-Q-2008-2600
EFSA-Q-2008-2611
EFSA-Q-2008-2613
EFSA-Q-2008-2654
EFSA-Q-2008-2667
EFSA-Q-2008-2673
EFSA-Q-2008-2674
EFSA-Q-2008-2690
EFSA-Q-2008-2699
EFSA-Q-2008-2702
EFSA-Q-2008-2704
EFSA-Q-2008-2721
EFSA-Q-2008-2722
EFSA-Q-2008-2732
EFSA-Q-2008-2753
EFSA-Q-2008-2754
EFSA-Q-2008-2758
EFSA-Q-2008-2776
EFSA-Q-2008-2782
EFSA-Q-2008-2792
EFSA-Q-2008-2793
EFSA-Q-2008-2794
EFSA-Q-2008-2816
EFSA-Q-2008-2820
EFSA-Q-2008-2823
EFSA-Q-2008-2858
EFSA-Q-2008-2865
EFSA-Q-2008-2869
EFSA-Q-2008-2877
EFSA-Q-2008-2884
EFSA-Q-2008-2887
EFSA-Q-2008-2889
EFSA-Q-2008-2914
EFSA-Q-2008-2921
EFSA-Q-2008-2926
EFSA-Q-2008-2996
EFSA-Q-2008-3054
EFSA-Q-2008-3208
EFSA-Q-2008-3244
EFSA-Q-2008-3374
EFSA-Q-2008-3386
EFSA-Q-2008-3387
EFSA-Q-2008-3401
EFSA-Q-2008-3406
EFSA-Q-2008-3467
EFSA-Q-2008-3528
EFSA-Q-2008-3533
EFSA-Q-2008-3550
EFSA-Q-2008-3556
EFSA-Q-2008-3565
EFSA-Q-2008-3568
EFSA-Q-2008-3582
EFSA-Q-2008-3587
EFSA-Q-2008-3588
EFSA-Q-2008-3590
EFSA-Q-2008-3599
EFSA-Q-2008-3898
EFSA-Q-2008-3900
EFSA-Q-2008-3901
EFSA-Q-2008-3906
EFSA-Q-2008-3907
EFSA-Q-2008-3908, EFSA-Q-2008-3909, EFSA-Q-2008-3915, EFSA-Q-2008-3932, EFSA-Q-2008-3944, EFSA-Q-2008-3948, EFSA-Q-2008-3964, EFSA-Q-2008-3973, EFSA-Q-2008-3988, EFSA-Q-2008-4001
EFSA-Q-2008-4009, EFSA-Q-2008-4022, EFSA-Q-2008-4029, EFSA-Q-2008-4031, EFSA-Q-2008-4039, EFSA-Q-2008-4047, EFSA-Q-2008-4048, EFSA-Q-2008-4068, EFSA-Q-2008-4080, EFSA-Q-2008-4084
EFSA-Q-2008-4087, EFSA-Q-2008-4093, EFSA-Q-2008-4105, EFSA-Q-2008-4114, EFSA-Q-2008-4117, EFSA-Q-2008-4129, EFSA-Q-2008-4135, EFSA-Q-2008-4138, EFSA-Q-2008-4141, EFSA-Q-2008-4147
EFSA-Q-2008-4152, EFSA-Q-2008-4166, EFSA-Q-2008-4173, EFSA-Q-2008-4177, EFSA-Q-2008-4183, EFSA-Q-2008-4185, EFSA-Q-2008-4189, EFSA-Q-2008-4197, EFSA-Q-2008-4211, EFSA-Q-2008-4212
EFSA-Q-2008-4221, EFSA-Q-2008-4232, EFSA-Q-2008-4234, EFSA-Q-2008-4247, EFSA-Q-2008-4251, EFSA-Q-2008-4267, EFSA-Q-2008-4275, EFSA-Q-2008-4297, EFSA-Q-2008-4318, EFSA-Q-2008-4322
EFSA-Q-2008-4331, EFSA-Q-2008-4370, EFSA-Q-2008-4376, EFSA-Q-2008-4385, EFSA-Q-2008-4401, EFSA-Q-2008-4402, EFSA-Q-2008-4424, EFSA-Q-2008-4428, EFSA-Q-2008-4435, EFSA-Q-2008-4451
EFSA-Q-2008-4486, EFSA-Q-2008-4499, EFSA-Q-2008-4505, EFSA-Q-2008-4509, EFSA-Q-2008-4514, EFSA-Q-2008-4517, EFSA-Q-2008-4530, EFSA-Q-2008-4532, EFSA-Q-2008-4533, EFSA-Q-2008-4534
EFSA-Q-2008-4539, EFSA-Q-2008-4541, EFSA-Q-2008-4542, EFSA-Q-2008-4545, EFSA-Q-2008-4552, EFSA-Q-2008-4554, EFSA-Q-2008-4555, EFSA-Q-2008-4565, EFSA-Q-2008-4570, EFSA-Q-2008-4572
EFSA-Q-2008-4604, EFSA-Q-2008-4615, EFSA-Q-2008-4632, EFSA-Q-2008-4721, EFSA-Q-2008-4861, EFSA-Q-2008-4874
Adopted
15 October 2009
Published
25 February 2010
Affiliation
European Food Safety Authority (EFSA), Parma, Italy
Note
Article (718.49 KB)718.49 KB
Summary

Following a request from the European Commission, the Panel on Dietetic Products, Nutrition and Allergies was asked to provide a scientific opinion on a list of health claims pursuant to Article 13 of Regulation (EC) No 1924/2006. This opinion addresses the scientific substantiation of health claims in relation to food(s)/food constituent(s) and the following claimed effects: protection of cells from premature aging, antioxidant, antioxidant content and antioxidant properties, and protection of DNA, proteins and lipids from oxidative damage. The scientific substantiation is based on the information provided by the Member States in the consolidated list of Article 13 health claims and references that EFSA has received from Member States or directly from stakeholders.

Protection of cells from premature aging

The claimed effects are “antioxidant activity” and “antioxidant properties”. The target population is assumed to be the general population. The proposed wordings include “protect cells from premature aging”, “antioxidant containing foods support of healthy aging”. The Panel considers that the claimed effect “protect cells from premature aging” does not comply with the criteria laid down in Regulation (EC) No 1924/2006.

Antioxidant activity, antioxidant content, and antioxidant properties

The claimed effects are “antioxidant activity/content” and/or “antioxidant properties”. The target population is assumed to be the general population. The Panel assumes that these claimed effects refer to the capacity of food/constituents to scavenge free radicals and/or to their reducing capacity. The Panel considers that no evidence has been provided to establish that having antioxidant activity/content and/or antioxidant properties is a beneficial physiological effect.

On the basis of the data presented, the Panel concludes that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s) evaluated in this opinion and a beneficial physiological effect related to antioxidant activity, antioxidant content, or antioxidant properties.

Protection of DNA, proteins and lipids from oxidative damage

The claimed effects refer to the protection of body cells and molecules (such as DNA, proteins and lipids) from oxidative damage, including UV-induced oxidative damage. The target population is assumed to be the general population. The Panel considers that the protection of molecules such as DNA, proteins and lipids from oxidative damage may be a beneficial physiological effect.

No human studies which investigated the effects of the food(s)/food constituent(s) on reliable markers of oxidative damage to body cells or to molecules such as DNA, proteins and lipids have been provided in relation to any of the health claims evaluated in this opinion. The evidence provided in the animal and in vitro studies submitted is not sufficient to predict the occurrence of an effect of the food(s)/food constituent(s) on the protection of body cells and molecules such as DNA, proteins and lipids from oxidative damage in vivo in humans.

On the basis of the data presented, the Panel concludes that a cause and effect relationship has not been established between the consumption of the food(s)/food constituent(s) evaluated in this opinion and the protection of body cells and molecules such as DNA, proteins and lipids from oxidative damage.

Keywords
Antioxidants, oxidative damage, DNA, lipids, proteins, ageing, health claims
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Number of Pages
63