Literature search and review related to specific preparatory work in the establishment of Dietary Reference Values - Preparation of an evidence report identifying health outcomes upon which Dietary Reference Values could potentially be based for magnesium, potassium and fluoride
Accepted: 14 Mai 2012
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Project developed on the procurement project CFT/EFSA/NDA/2010/02 (Lot 3)
The aim of these systematic searches and reviews was to collate all of the scientific data from which Dietary Reference Values for magnesium (Mg), potassium (K) and fluoride (F) may be derived, building on existing information in the Scientific Committee for Food Dietary Reference Values report of 1993.
In March, September and October 2011, electronic searches were run after rigorous development and optimisation of the complex search strategy (which included indexing and text terms, truncation and Boolean operators). Databases searched were Medline, EMBASE (both on Ovid SP) and the Cochrane Library CENTRAL. Additional references were identified by checking reference lists in key reviews, included studies and DRV reports.
Search results were imported into EndNote®, duplicates were removed and the library was then screened for studies that appeared to be relevant. Each full-text article retrieved was assessed using an inclusion/exclusion form. The literature search focused on: 1) data published in the English language from 1990 onwards; 2) human studies conducted in generally healthy populations; 3) studies which examined the relationship between micronutrient intake, status, and/or health; and 4) studies which were relevant to micronutrient intakes within the normal dietary/physiological range.
A total of 7887 articles (Mg n=3123; K n=2583; F n=2181) were screened on the basis of title and abstract, resulting in the selection of 848 articles (Mg n=359; K n=235; F n=254) for full-text assessment, and the final inclusion of 135 studies (Mg n=48; K n=44; F n=43) for this review. Data on the study design, methods and results were extracted and study quality was assessed. All stages in the process were duplicated by researchers at a level of 10% to ensure consistency in data recording.
Included studies reported on: micronutrient bioavailability; nutrient interactions; metabolism; status markers; breast milk micronutrient concentration; polymorphisms; and micronutrient specific health outcomes (cardiovascular risk factors; blood pressure; bone health; tooth health; aldosterone and renin; diabetes; metabolic rate; sleep; and leptin levels). The majority of studies identified were assessed as being at high risk of bias (n=119), with the remainder of studies at moderate (n=12) or low risk of bias (n=4). Data were generally more limited for children (with the exception of fluoride studies addressing tooth health). Overall, there appeared to be a lack of high quality studies on which to base Dietary Reference Values for magnesium, potassium and fluoride.Veröffentlicht: 22 Mai 2012