Efficacy of Cylactin® (Enterococcus faecium NCIMB 10415) as a feed additive for pigs for fattening

Zootechnical additive, gut flora stabilisers, Cylactin®, Enterococcus faecium, pigs for fattening, efficacy
First published in the EFSA Journal
20. März 2018
Adopted
21. Februar 2018
Type
Scientific Opinion

Abstract

Cylactin® is the trade name for a feed additive based on dehydrated cells of Enterococcus faecium. It is marketed in three forms: Cylactin® LBC ME10 and Cylactin® LBC ME20 Plus – which contain the microencapsulated bacterium in concentrations of 1 × 1010 CFU/g and 2 × 1010 CFU/g, respectively – and Cylactin® LBC G35, a granulated form with a guaranteed content of 3.5 × 1010 CFU/g. In 2012, EFSA was requested by the European Commission to re-evaluate the product when used as a zootechnical additive in feed for weaned piglets, sows and pigs for fattening. In the opinion delivered in 2015, the safety of the additive for consumers, users, the environment and target animals and its efficacy for piglets and sows were established. However, since only two efficacy studies with pigs for fattening could be considered and showed positive results, the Panel could not conclude on the efficacy for this target species due to insufficient data. The applicant has produced three additional feeding trials in pigs for fattening receiving the additive at the proposed inclusion level of 3.5 × 108 CFU/kg feedingstuffs, which are the subject of this assessment. None of these studies showed a significant effect on the performance of pigs for fattening. The data on average daily gain and feed to gain ratio of the three new studies and of the two from the previous opinion were pooled. Based on the results of this pooled analysis of five studies, but not supported by four out of the five individual studies, the EFSA Panel on Additives and Products or Substances used in Animal Feed concludes that Cylactin® has some potential to improve performance of pigs for fattening at 3.5 × 108 CFU/kg feed.

Panel members at the time of adoption

Gabriele Aquilina, Giovanna Azimonti, Vasileios Bampidis, Maria de Lourdes Bastos, Georges Bories, Andrew Chesson, Pier Sandro Cocconcelli, Gerhard Flachowsky, Jürgen Gropp, Boris Kolar, Maryline Kouba, Marta López-Alonso, Secundino López Puente, Alberto Mantovani, Baltasar Mayo, Fernando Ramos, Guido Rychen, Maria Saarela, Roberto Edoardo Villa, Robert John Wallace and Pieter Wester.
Panel on Additives and Products or Substances used in Animal Feed
Contact
feedap [at] efsa.europa.eu
doi
10.2903/j.efsa.2018.5201
EFSA Journal 2018;16(3):5201
Question Number
On request from
European Commission